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...in the form of citrulline malate is sold as a performance-enhancing athletic dietary supplement which is said to reduce muscle fatigue... |
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| Quality Citrulline from 'House Of Nutrition' | |
Allergy Research's L-Citrulline Powder 100 gm
L-Citrulline is a non-essential amino acid that is an important intermediate in the urea cycle, functioning along with L-Arginine and L-Ornithine to rid the body of ammonia, a byproduct of protein metabolism. Because L-Citrulline is a precursor of L-Arginine, it provides a readily available source material for L-Arginine production, which in turn, can be used for the production of Nitric Oxide (NO). NO plays a fundamental role in vascular function and blood flow. L-Citrulline therefore, not only supports detoxification pathways, but also supports NO production and a healthy cardiovascular system... |
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Citrulline |
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Now's L-Citrulline 100% Pure Powder 4oz The Best Curent Available Price ! Promotes Cardiovascular Health. Promotes Nitric Oxide Production. Supports Vascular Blood Flow. GMP Quality Assured. A Dietary Supplement Vegetarian Product Citrulline is a non-essential amino acid that is an important intermediate in the urea cycle, functioning along with Arginine and Ornithine to rid the body of ammonia, a byproduct of protein metabolism. Because Citrulline is a precursor of Arginine, it provides a readily available source material for Arginine production, which in turn, can be used for the production of Nitric Oxide (NO). NO plays a fundamental role in vascular function and blood flow. Citrulline therefore, not only supports detoxification pathways, but also supports NO production and a healthy cardiovascular system... |
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Now's L-Citrulline 750mg 180Caps L-Citrulline is a non-essential amino acid that is an important intermediate in the urea cycle, functioning along with L-Arginine and L-Ornithine to rid the body of ammonia, a byproduct of protein metabolism. Because L-Citrulline is a precursor of L-Arginine, it provides a readily available source material for L-Arginine production, which in turn, can be used for the production of Nitric Oxide (NO). NO plays a fundamental role in vascular function and blood flow. L-Citrulline therefore, not only supports detoxification pathways, but also supports NO production and a healthy cardiovascular system... |
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Solaray's Citrulline Malate 60Vcaps L-Citrulline is a non-essential amino acid that is a necessary factor in the release of nitric oxide... |
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Citrulline
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Watermelon
WatermelonL-Citrulline
...is the organic compound citrulline which is an α-amino acid.
When starved for arginine, organisms will convert ornithine to citrulline, which in turn gives arginine.
Patients with rheumatoid arthritis often (at least 80% of them) develop an immune response against proteins containing citrulline.
Although the origin of this immune response is not known, detection of antibodies reactive with citrulline containing proteins or peptides is now becoming an important help in the diagnosis of rheumatoid arthritis.
Citrulline in the form of citrulline malate is sold as a performance-enhancing athletic dietary supplement which is said to reduce muscle fatigue.
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From The Article In Wikipedia... Feb 22, 2009
The organic compound citrulline is an α-amino acid.
Its name is derived from citrullus, the Latin word for watermelon, from which it was first isolated in 1930.
It has the idealized formula H2NC(O)NH(CH2)3CH(NH2)CO2H.
It is a key intermediate in the urea cycle, the pathway by which mammals excrete ammonia.
Biosynthesis
Citrulline is made from ornithine and carbamoyl phosphate in one of the central reactions in the urea cycle.
It is also produced from arginine as a by-product of the reaction catalyzed by NOS family (NOS; EC 1.14.13.39).
Arginine is first oxidized into N-hydroxyl-arginine, which is then further oxidized to citrulline concomitant with release of nitric oxide.
Function
Although citrulline is not coded for by DNA directly, several proteins are known to contain citrulline as a result of a posttranslational modification.
These citrulline residues are generated by a family of enzymes called peptidylarginine deiminases (PADs), which convert arginine into citrulline in a process called citrullination or deimination.
Proteins that normally contain citrulline residues include myelin basic protein (MBP), filaggrin, and several histone proteins, whereas other proteins, such as fibrin and vimentin are susceptible to citrullination during cell death and tissue inflammation.
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Patients with rheumatoid arthritis often have detectable antibodies against proteins containing citrulline.
Although the origin of this immune response is not known, detection of antibodies reactive with citrulline (anti-citrullinated protein antibodies) containing proteins or peptides is now becoming an important help in the diagnosis of rheumatoid arthritis.
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In recent studies, citrulline has been found to relax blood vessels.
Sources
Citrulline in the form of citrulline malate is sold as a performance-enhancing athletic dietary supplement which is said to reduce muscle fatigue.
The rind of watermelon (Citrullus lanatus) is a good natural source of citrulline. *
| Citrulline | |
|---|---|
  |
|
| IUPAC name | 2-Amino-5-(carbamoylamino) pentanoic acid |
| Identifiers | |
| CAS number | 372-75-8 |
| PubChem | 9750 |
| Properties | |
| Molecular formula | C6H13N3O3 |
| Molar mass | 175.19 g mol−1 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references |
|
*
Read the complete Article in Wikipedia, Feb 22, 2009
*Citrulline. (2009, January 22). In Wikipedia, The Free Encyclopedia.
Retrieved 12:43, February 22, 2009,
http://en.wikipedia.org/w/index.php?title=
Citrulline&oldid=265709223
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Read the complete Article in Wikipedia June 8, 2011
** Citrulline. (2011, May 12). In Wikipedia, The Free Encyclopedia.
Retrieved 21:57, June 8, 2011, from
http://en.wikipedia.org/w/index.php?title=
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Citrullinemia
Citrullinemia, also called citrullinuria, is an autosomal recessive urea cycle disorder that causes ammonia and other toxic substances to accumulate in the blood.
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Two forms of citrullinemia have been described, both having different signs and symptoms, and are caused by mutations in different genes.
Citrullinemia belongs to a class of genetic diseases called urea cycle disorders.
The urea cycle is a sequence of chemical reactions that takes place in the liver.
These reactions process excess nitrogen, generated when protein is used by the body, to make a compound called urea that is excreted by the kidneys.
Types
Type I
Type I citrullinemia (Online 'Mendelian Inheritance in Man' (OMIM) 215700, also known as classic citrullinemia) usually becomes evident in the first few days of life.
Affected infants typically appear normal at birth, but as ammonia builds up in the body they develop a lack of energy (lethargy), poor feeding, vomiting, seizures, and loss of consciousness.
These medical problems can be life-threatening in many cases.
Less commonly, a milder form of type I citrullinemia can occur in childhood or adulthood.
Some people with gene mutations that cause type I citrullinemia never experience signs and symptoms of the disorder.
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Type I citrullinemia is the most common form of the disorder, affecting about 1 in 57,000 births worldwide.
Mutations in the ASS gene cause type I citrullinemia.
The enzyme made by this gene, argininosuccinate synthetase (EC 6.3.4.5), is responsible for one step of the urea cycle.
Mutations in the ASS gene reduce the activity of the enzyme, which disrupts the urea cycle and prevents the body from processing nitrogen effectively.
Excess nitrogen, in the form of ammonia, and other byproducts of the urea cycle accumulate in the bloodstream, leading to the characteristic features of type I citrullinemia.
Type II
The signs and symptoms of type II citrullinemia (Online 'Mendelian Inheritance in Man' (OMIM) 605814 and Online 'Mendelian Inheritance in Man' (OMIM) 603471) usually appear during adulthood and mainly affect the nervous system.
Characteristic features include confusion, abnormal behaviors (such as aggression, irritability, and hyperactivity), seizures, and coma.
These signs and symptoms can be life-threatening, and are known to be triggered by certain medications, infections, and alcohol intake in people with type II citrullinemia.
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Type II citrullinemia may also develop in people who had a liver disorder called neonatal intrahepatic cholestasis during infancy.
This condition blocks the flow of bile and prevents the body from processing certain nutrients properly.
In many cases, the signs and symptoms resolve within a year.
Years or even decades later, however, some of these people develop the characteristic features of adult type II citrullinemia.
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Type II citrullinemia is primarily found in the Japanese population, where it occurs in an estimated 1 in 100,000 to 230,000 individuals.
Type II has also been reported in people from East Asian and Middle Eastern populations.
Mutations in the SLC25A13 gene are responsible for type II citrullinemia.
This gene makes a protein called citrin, which normally shuttles certain molecules in and out of mitochondria.
These molecules are essential for the urea cycle and are also involved in making proteins and nucleotides.
Mutations in the SLC25A13 mutation typically prevent the production of any functional citrin, which inhibits the urea cycle and disrupts the production of proteins and nucleotides.
The resulting buildup of ammonia and other toxic substances leads to the signs and symptoms of type II citrullinemia.
Researchers have determined that many infants with neonatal intrahepatic cholestasis have the same mutations in the SLC25A13 gene as adults with type II citrullinemia. *
| Citrullinemia Classification and external resources |
||
 |
||
|---|---|---|
| Citrulline | ||
| ICD-10 | E72.2 | |
| ICD-9 | 270.6 | |
| OMIM | 215700 605814 603471 | |
| DiseasesDB | 29676 34048 | |
| eMedicine | ped/406 | |
| MeSH | C10.228.140.163.100.175 | |
*
Read The complete article on Citrullinemia oct 8, 2008
*Citrullinemia. (2008, October 8).
In Wikipedia, The Free Encyclopedia.
Retrieved 12:47, February 22, 2009,from
http://en.wikipedia.org/w/index.php?title=
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Read The complete article on Citrullinemia June 8, 2011
** Citrullinemia. (2011, January 20). In Wikipedia, The Free Encyclopedia.
Retrieved 22:00, June 8, 2011,
://en.wikipedia.org/w/index.php?title=
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See references for complete information including notes, comments, complete symptoms, sources, concerns and cautions.
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Disclaimer :
In accordance with FDA regulation, we do not make any therapeutic claims for any Dietary Supplements in accordance with the Dietary Supplement Health and Education Act.
Information on this website is provided for informational purposes only and is not intended as a substitute for the advice provided by your physicians, health care professional or other professional. You should not use the information on this website for diagnosing or treating any health problem, symptom or disease, prescribing any medication or other treatment, or in place of any other professional advice. This information is not intended to diagnose, treat, cure or prevent any diseases. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. Your discretion is advised.
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