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GABA molecule

Gamma Aminobutyric Acid(GABA)

GABA is the chief inhibitory neurotransmitter in the central nervous system, is directly responsible for the regulation of muscle tone....

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Gamma-aminobutyric acid (GABA) is an amino acid that does not get incorporated into proteins, but instead plays an important role in regulating the activity of nerve cells.

It is the chief inhibitory neurotransmitter in the central nervous system and in the retina, and can also be excitatory under some circumstances.

GABA is closely related to another biomolecule called GHB (gamma-hydroxybutyrate); GABA and GHB are interconvertible in the brain.

GHB was a very useful and inexpensive supplement for promoting relaxation and sleep until it was foolishly banned in the U.S. and other countries as part of the fiasco known as the "War-On-Drugs".

GHB, unlike GABA, readily crosses the blood-brain barrier; once in the brain, GHB is converted into GABA which then calms over-excited nerves.

Since GABA crosses the blood-brain barrier less easily than GHB, larger doses are required to achieve the same goals.

 

The Wikipedia offers a good overview of GABA and its actions in the body.

A less technical review from "Iron Magazine" is also useful despite its uncritical acceptance of government-spawned propaganda about GHB.

 

What we can't tell you in the U.S. and some other industrialized countries, government agencies like the U.S. Food and Drug Administration have adopted censorship as a method for intensifying their control over the supplement industry and its customers.

Thus, FDA regulations prohibit us from telling you that any of our products are effective as medical treatments, even if they are, in fact, effective.

Accordingly, we will limit our discussion of GABA to a brief summary of relevant research, and let you draw your own conclusions about what medical conditions it may be effective in treating.

As a supplement, GABA has received less attention from medical researchers than it deserves.

The handful of scientifically conducted clinical trials that have been conducted since 1980 have reported positive results with certain usages of GABA, but many interesting applications have never been investigated scientifically.

GABA supplementation has been shown to be effective for: stimulating the pituitary gland to secrete more Human Growth Hormone, Increasing protein synthesis in brain, muscle, and liver, inducing relaxation, reducing anxiety, enhancing immunity during stress, reducing high blood pressure, increasing blood insulin levels.

In addition to the directly demonstrated actions listed above, the following actions are suggested by indirect scientific evidence: improve schizophrenic symptoms, promote loss of excess body fat, build muscle. And then there are the GABA usages that have never been properly investigated scientifically.

For these we have to rely on anecdotal evidence: anti-aging... making users feel youthful and energetic improving the skin, darkening hair, inducing sleep, improving the quality of sleep, causing more interesting, vivid dreaming, diminishing arthritis pain and lower back pain reducing symptoms.

 

GABA GABA structure

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GABA is the chief inhibitory neurotransmitter in the mammalian central nervous system.

It plays an important role in regulating neuronal excitability throughout the nervous system.

In humans, GABA is also directly responsible for the regulation of muscle tone.

 

GABA acts as a neurotransmitter in the central nervous system, it is essential for brain metabolism, aiding in proper brain function.

 

GABA Promotes Relaxation & Mental Focus.

GABA is a superior source and naturally produced form of the important brain compound gamma-amino butyric acid (GABA).

Clinical studies have shown GABA helps to increase the production of alpha brain waves to create a profound sense of physical relaxation while maintaining mental focus.

 

GABA GABA molecule

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GABA is a non-essential amino acid found mainly in the human brain and eyes.

It is considered an inhibitory neurotransmitter, which means it regulates brain and nerve cell activity by inhibiting the number of neurons firing in the brain.

GABA is referred to as the "brain's natural calming agent".

By inhibiting over-stimulation of the brain, GABA may help promote relaxation and ease nervous tension.

 

 

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GABA

While technically an amino acid, GABA is rarely referred to as such in the scientific or medical communities, because the term "amino acid," used without a qualifier, refers to the alpha amino acids, which GABA is not, nor is it incorporated into proteins.

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In spastic diplegia in humans, GABA absorption by some nerves becomes damaged, which leads to hypertonia of the muscles signaled by those nerves.

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In the developmental stages preceding the formation of synaptic contacts, GABA is synthesized by neurons and acts both as an autocrine (acting on the same cell) paracrine (acting on nearby cells) signalling mediator.

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GABA regulates the proliferation of neural progenitor cells the migrationand differentiation the elongation of neurites and the formation of synapses.

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GABA also regulates the growth of embryonic and neural stem cells.

History

Gamma-aminobutyric acid was first synthesized in 1883, and was first known only as a plant and microbe metabolic product.

In 1950, however, GABA was discovered to be an integral part of the mammalian central nervous system.

Synthesis

Organisms synthesize GABA from glutamate using the enzyme L-glutamic acid decarboxylase and pyridoxal phosphate (which is the active form of B6) as a cofactor.

This process converts the principal excitatory neurotransmitter (glutamate) into the principal inhibitory one (GABA).

Pharmacology

Drugs that act as agonists of GABA receptors (known as GABA analogues or GABAergic drugs) or increase the available amount of GABA typically have relaxing, anti-anxiety and anti-convulsive effects.

Spastic diplegia, a GABA deficiency neuromuscular neuropathology. *

* Read the article in Wikipedia with references and links Feb 24, 2009

** Read an article in Wikipedia with references and links June 11, 2012

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GABA

GABA is an amino acid derivative, and a key inhibitory neurotransmitter.

Neurotransmitters are chemical messengers that carry information between nerve cells or from nerve cells to other target cells.

GABA has an inhibitory effect on the firing of neurons and supports a calm mood.

GABA is synthesized directly from glutamic acid.

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In accordance with FDA regulation, we do not make any therapeutic claims for any Dietary Supplements in accordance with the Dietary Supplement Health and Education Act.

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