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Methylsulfonylmethane (MSM) occurs naturally in some primitive plants and is present in small amounts in many foods and beverages and it is marketed as a dietary supplement, although its benefits are disputed....
....Continued Below |
Quality MSM from 'Mother Nature' |
Country Life MSM, 500 mg- 90 tab
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MSM is a natural form of sulfur, an essential trace mineral. Sulfur is essential for numerous electrochemical catalytic and structural functions in human metabolism. |
Food Science of Vermont MSM, 1000 mg- 180 tab
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A dietary supplement to support joint function and skin health.* This naturally-occurring sulfur compound has a vitamin-like normalizing influence on body functions. A low concentration of sulfur blood levels has been associated with both psychological and physical stress, organ and tissue malfunction, fatigue and susceptibility to disease. Supplementation with MSM supports joint comfort as well as collagen and skin health.* |
MSM Growing Herbs
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Nature's Way FlexMax Glucosamine with MSM, 80 tab
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FlexMax Glucosamine with MSM, 80 tablets, Nature's WayFlexMax Glucosamine with MSM combines clinically researched glucosamine sulfate with sulfur-rich MSM for double effectiveness. An advancement over competitive brands, FlexMax is non-irritating to the stomach because of its proprietary StomachGuard technology that utilizes plant fibers to form a protective gel around the tablet upon entering the digestive tract. This natural gel provides a cushioning effect and regulates the release of glucosamine, thus shielding against potential stomach irritation. Nature's Way FlexMax can be comfortably taken at any time of the day, with or without a meal. Usage: Provides powerful nutritional support for healthy joints by lubricating and nourishing damaged tissue and cartilage. Successfully used by athletes as well as maturing adults concerned about maintaining joint flexibility and comfort. Ideal for hands, wrists, knees, back, neck, elbows, hips and ankles.*Recommended Daily Dosage: Take two tablets twice daily with water. The following list is for serving size of 2Tablets. Primary Ingredients: Glucosamine Sulfate 750 mg Methyl Sulfonyl Methane (MSM) 750 mg. Other Ingredients: Cellulose, Glycerin, Maltodextrin, Modified Cellulose Gum, Silica, Stearic Acid. Quality Issues: Sodium free. FlexMax glucosamine sulfate is preferred by people concerned about high blood pressure because it is processed with potassium chloride (table salt) as found in other brands. Usage Warnings: This product is double safety sealed with a printed outer shrink-wrap film and printed inner bottle freshness seal. Do not use if either seal is broken or missing.* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. |
Solgar Glucosamine Hyaluronic Acid Chondroitin MSM (Shellfish-Free), 60 tab
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Solgar Glucosamine Hyaluronic Acid Chondroitin MSM (Shellfish-Free), 60 tab |
Quality MSM from 'Kalyx'
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MSM (Methylsulfonylmethane), 1 lb: K
From Frontier Naturals
The Best Current Available Price !

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Methyl Sulfonyl Methane. MSM is also called 'organic sulfur,' naturally occurring sulfur. You find it in rain -- and in all plants and animals. It is widely used around the world for relief of pain from arthritis, back pain or muscle pain. There is no known toxic level of usage. In its purified chemical form, it is an odorless, essentially tasteless, white, water soluble crystalline solid. It is one of the least toxic substances in biology, similar in toxicity to water. MSM is a relative to dimethyl sulfoxide (DMSO), a unique therapeutic agent used worldwide in the treatment of many painful and inflammatory conditions. MSM has many of DMSO's properties, but without the oyster-like odor and other side effects. Naturally-occurring sulfur, such as that found in MSM, is not similar to inorganic sulfides, sulfites and sulfates to which many people are allergic. Some of MSM's essential functions in the body include maintaining the structure of the proteins in the body, helping the formation of keratin which is essential for hair and nail growth, aiding in the production of immunoglobulin which maintains the immune system, and catalyzing the chemical reactions which change food into energy. Many years of clinical use at Oregon Health Sciences University has demonstrated that MSM provides the following pain relief and anti-inflammatory benefits without serious side effects: Inhibition of pain impulses along nerve fibers (analgesia) Lessening of inflammation Increase in blood supply Reduction of muscle spasm Softening of scar tissue MSM is often so effective for pain relief that doctors are able to lower the dosage of medication they prescribe for patients. Sometimes, they are even able to discontinue the medication altogether. The end result is relief along with fewer or no side effects that are frequently caused by prescriptive medications. |
MSM 
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MSM Ultrapure Fine Powder 16 oz.
From Health and Herbs
The Best Current Available Price !

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Methyl Sulfonyl Methane. MSM is also called 'organic sulfur,' naturally occurring sulfur. You find it in rain -- and in all plants and animals. It is widely used around the world for relief of pain from arthritis, back pain or muscle pain. There is no known toxic level of usage. In its purified chemical form, it is an odorless, essentially tasteless, white, water soluble crystalline solid. It is one of the least toxic substances in biology, similar in toxicity to water. MSM is a relative to dimethyl sulfoxide (DMSO), a unique therapeutic agent used worldwide in the treatment of many painful and inflammatory conditions. MSM has many of DMSO's properties, but without the oyster-like odor and other side effects. Naturally-occurring sulfur, such as that found in MSM, is not similar to inorganic sulfides, sulfites and sulfates to which many people are allergic. Some of MSM's essential functions in the body include maintaining the structure of the proteins in the body, helping the formation of keratin which is essential for hair and nail growth, aiding in the production of immunoglobulin which maintains the immune system, and catalyzing the chemical reactions which change food into energy. Many years of clinical use at Oregon Health Sciences University has demonstrated that MSM provides the following pain relief and anti-inflammatory benefits without serious side effects: Inhibition of pain impulses along nerve fibers (analgesia) Lessening of inflammation Increase in blood supply Reduction of muscle spasm Softening of scar tissue MSM is often so effective for pain relief that doctors are able to lower the dosage of medication they prescribe for patients. Sometimes, they are even able to discontinue the medication altogether. The end result is relief along with fewer or no side effects that are frequently caused by prescriptive medications. |
MSM Growing herbs
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Emu-MSM Pain Cream, 1.75 oz: HH
From Health and Herbs
The Best Current Available Price !

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For use as an anti-inflammatory for joint pain, arthritis, tendonitis, strains, sore muscles, back, headaches, and more. |
MSM Making Herbal Remedies
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MSM/Glucosamine: 1 lb: C
Fropm StarWest Botanicals
The Best Current Available Price !
 
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This is Starwest's nitrogen-flushed double wall silverfoil pack. Used as a dietary supplement, either added to food or drink or encapsulated. Methyl Sulfonyl Methane. MSM is also called 'organic sulfur,' naturally occurring sulfur. You find it in rain -- and in all plants and animals. It is widely used around the world for relief of pain from arthritis, back pain or muscle pain. There is no known toxic level of usage. In its purified chemical form, it is an odorless, essentially tasteless, white, water soluble crystalline solid. It is one of the least toxic substances in biology, similar in toxicity to water. MSM is a relative to dimethyl sulfoxide (DMSO), a unique therapeutic agent used worldwide in the treatment of many painful and inflammatory conditions. MSM has many of DMSO's properties, but without the oyster-like odor and other side effects. Naturally-occurring sulfur, such as that found in MSM, is not similar to inorganic sulfides, sulfites and Sulphates to which many people are allergic. Some of MSM's essential functions in the body include maintaining the structure of the proteins in the body, helping the formation of keratin which is essential for hair and nail growth, aiding in the production of immunoglobulin which maintains the immune system, and catalyzing the chemical reactions which change food into energy. Many years of clinical use at Oregon Health Sciences University has demonstrated that MSM provides the following pain relief and anti-inflammatory benefits without serious side effects: Inhibition of pain impulses along nerve fibers (analgesia) Lessening of inflammation Increase in blood supply Reduction of muscle spasm Softening of scar tissue MSM is often so effective for pain relief that doctors are able to lower the dosage of medication they prescribe for patients. Sometimes, they are even able to discontinue the medication altogether. The end result is relief along with fewer or no side effects that are frequently caused by prescriptive medications. Glucosamine sulphate is produced from shrimp shells, which have esentially the same biochemistry as human cartilage. Glucosamine is not only safe but an active supporter of proteoglycan synthesis (i.e., a producer of cartilage macromolecules consisting of a protein bound to a glucosaminoglycan). There is increasing evidence that Glucosamine does in fact relieve joint pain and inflammation for many arthritis sufferers, and that it may slow progression of the disease. Because of its ability to reduce and--in some cases--completely eliminate the pain of osteoarthritis, some physicians and researchers feel Glucosamine might offer similar benefits for people suffering from rheumatoid arthritis, ankylosing spondylitis, spinal disc degeneration, tendinitis, bursitis, and physical injuries to the joints. There is even speculation that it could play a preemptive role, eliminating the development of osteoarthritis. |
Quality MSM from 'House Of Nutrition'
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BlueBonnet's Glucosamine Chondroitin Plus MSM 60Vcaps
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Glucosamine Chondroitin Plus MSM Vcaps. Description: Glucosamine and Chondroitin Sulfate, Dietary Supplement. Pure Flex. OptiMSMBluebonnet's Glucosamine Chondroitin Plus MSM Vcaps provide a potent, synergistic blend of joint-supporting nutrients per serving, such as: pure glucosamine sulfate (1000 mg), chondroitin sulfate (500 mg) and OptiMSM® (500 mg), a superior active form of sulphur plus 500 mg of vitamin C from L-ascorbic acid. Available in easy-to-swallow vegetable capsules for maximum assimilation and absorption. Supplement Facts: Serving Size 3 Capsules. Vitamin C (L-ascorbic acid) 500 mg 833 Glucosamine Sulfate (shellfish) 1000 mg Chondroitin Sulfate 500 mg MSM (methylsulfonylmethane) 500 mg. Other Ingredients: 100% Kosher vegetable capsules, vegetable magnesium stearate. Contains: Crustacean shellfishFree of: milk, egg, fish, tree nuts, peanuts, wheat and soybeans.Also free of yeast, gluten, barley, rice and sugar. Directions: As a dietary supplement, take three capsules daily with meals or as directed by a healthcare practitioner. |
MSM Growing herbs
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Jarrow's MSM Sulfur 750mg 100Caps
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MSM Sulfur. Description: Jarrow FORMULAS® MSM Sulfur™ is an organic source of bioavailable sulfur. Sulfur is an antioxidant mineral found in major structural tissues of the body such as cartilage. The sulfur from MSM is used to produce glycosaminoglycans (or mucopolysaccharides) such as chondroitin sulfate, dermatan sulfate, and hyaluronic acid.* These sulfur containing glycosaminoglycans are found in high concentrations in connective tissues, including joint cartilage, skin and collagen. Other Ingredients: Magnesium stearate (vegetable source). Capsule consists of gelatin. No wheat, no gluten, no soybeans, no dairy, no egg, no fish/shellfish, no peanuts/tree nuts. Directions: Take 1 to 3 capsules per day, in divided doses, or as directed by your qualified health care consultant. Notes: For best results, use with Jarrow FORMULAS® JarroSil™, the biologically Activated Silicon™. Warnings: Keep out of the reach of children. If you have a medical condition, are pregnant, lactating, or trying to conceive, are under the age of 18, or are taking medications, consult your health care practitioner before using this product. |
MSM Live herbs
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Now's Liquid Glucosamine/Chondroitin/MSM 16oz
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Supports Joint Health. Description: Liquid Glucosamine & Chondroitin with MSM combines three of the most effective nutrients available today for supporting good joint health in an easily absorbed liquid form. Glucosamine and Chondroitin are naturally occurring structural components that are used by the body to support healthy joint function. MSM, Manganese and Vitamin C complement Glucosamine and Chondroitin and work synergistically with them to provide optimal nutritional support.* Supplement Facts: Serving Size: 1 tablespoon (15 ml). Servings per container: 32. Other Ingredients: Purified Water, Vegetable Glycerin, Fructose, Malic Acid, Xanthan Gum, Citric Acid, Potassium Sorbate, Sodium Benzoate and Natural Flavors. Directions: As a dietary supplement, take 1 tablespoon (15 ml) twice daily. Notes: Free of: yeast, wheat, gluten, corn, soy, milk or artificial colors. Warnings: Shake well before use. Refrigerate after opening to preserve flavor. |
Now's Hyaluronic Acid W/ Lignisul MSM 60Vcaps
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Hyaluronic Acid is a compound present in every tissue of the body, with the highest concentrations occurring in connective tissues such as skin and cartilage. Hyaluronic Acid is an important constituent of joint fluid where it serves as a lubricant and plays a role in resisting compressive forces.* Read FAQ's. Serving Size: 2 Vcaps®. Suggested Use: As a dietary supplement, take 2 Vcaps® 1-2 times daily, preferably with meals. Free of: sugar, starch, yeast, wheat, gluten, corn, soy, milk, egg or preservatives. Other Ingredients: Cellulose (capsule), Magnesium Stearate (vegetable source) and Silica. Warnings: Caution: Please discard the inedible freshness packet enclosed. Disclaimers: *This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. Lignisul® MSM is a registered trademark of Halton Health, Inc.Vcaps® is a registered trademark of Capsugel. |
MSM Herbal Remedies
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Now's Hyaluronic Acid W/ MSM 120Vcaps
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Description Joint Support Important Joint Lubricant* Vegetarian Formula A Dietary Supplement Hyaluronic Acid is a compound present in every tissue of the body, with the highest concentrations occurring in connective tissues such as skin and cartilage. Hyaluronic Acid is an important constituent of joint fluid, where it serves as a lubricant and plays a role in resisting compressive forces. Suggested Use As a dietary supplement, take 2 Vcaps® 1-2 times daily, preferably with meals. Supplement Facts: Serving Size: 2 Vcaps. Servings Per Container: 60. Amount Per Serving % Daily Value Sodium (from Sodium Hyaluronate) 9 mg <1% Hyaluronic Acid (from Sodium Hyaluronate) 100 mg, MSM (Methysulphonylmethane) 900 mg. Daily Value not established. Other Ingredients: Cellulose (capsule), Magnesium Stearate (vegetable source) and Silica. Contains no sugar, starch, yeast, wheat, gluten, corn, soy, milk, egg or preservatives. Warnings: Do not eat freshness packet. Keep in bottle. Store in a cool, dry place. Please recycle. |
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MSM
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MSM
Methylsulfonylmethane (MSM) is an organosulfur compound with the formula (CH3)2SO2. It is also known by several other names including DMSO2, methyl sulfone, and dimethyl sulfone. This colorless solid features the sulfonyl functional group and is considered relatively inert chemically. It occurs naturally in some primitive plants and is present in small amounts in many foods and beverages and it is marketed as a dietary supplement, although its benefits are disputed.
____________________
Structure and chemical properties
MSM is structurally related to dimethyl sulfoxide (DMSO), but the behavior of these two is different. DMSO is a highly polar solvent and an excellent ligand, with water-like dissolving properties whereas MSM is less polar and less reactive. MSM is also a metabolite of DMSO.
Use as a solvent
Because of its polarity and thermal stability, MSM is used industrially as a high-temperature solvent for both inorganic and organic substances. It is used as a medium in organic synthesis. For example, displacement of aryl chlorides by potassium fluoride can be usefully conducted in molten MSM. With a pKa of 31, it can be deprotonated with sodium amide, and the conjugate base is an effective nucleophile.
Effects on health
MSM is promoted as a natural source of sulfur by the supplement and health food industry. There is no Dietary Reference Intake (DRI) or Daily Value established for sulfur. MSM is sold as a dietary supplement that is marketed with a variety of claims, and is commonly used (often in combination with glucosamine and/or chondroitin) for helping to treat or prevent osteoarthritis. The biochemical effects of supplemental methylsulfonylmethane are poorly understood. Some researchers have suggested that MSM has anti-inflammatory effects. Any health effects of dimethyl sulfoxide (DMSO) may be mediated, at least in part, by MSM. Stanley W. Jacob, M.D., of the Oregon Health and Science University, reports using MSM to treat over 18,000 patients with a variety of ailments. According to one review, "The benefits claimed far exceed the number of scientific studies. It is hard to build a strong case for its use other than for treating arthritis problems."
Evidence from clinical trials
Clinical evidence for the usefulness of MSM consists of published studies on both animals and humans. These studies of MSM have suggested some benefits, particularly for treatment of osteoarthritis. Further studies would be needed to test the usefulness of the chemical as a medical therapy.
- Osteoarthritis: After several reports that MSM helped arthritis in animal models, a double-blind, placebo-controlled study suggested that 1500 mg per day MSM (alone or in combination with glucosamine sulfate) was helpful in relieving symptoms of knee osteoarthritis The results of the Usha clinical trial are suspect.It was conducted in India by researchers with very little prior experience in clinical trials. Tests are described in Methods but no data presented, and for other tests statements in Results and Discussion are not supported by the data shown. Discussion statements are not supported by the references cited. Placebo group results did not significantly change from baseline, whereas in osteoarthritis trials there is typically a 30-40% improvement in the placebo group. Kim et al. conducted a double-blind clinical trial of MSM for treatment of patients with osteoarthritis of the knee. Twenty-five patients took 6000 mg/day MSM and 25 patients took a placebo for 12 weeks. Ten patients did not complete the study, and intention to treat analysis was performed. Patients who took MSM had significantly reduced pain and improved physical functioning, without major adverse events. No evidence of a more general anti-inflammatory effect was found, as there were no significant changes in two measures of systemic inflammation: C-reactive protein level and erythrocyte sedimentation rate. The authors cautioned that this short pilot study did not address the long-term safety and usefulness of MSM, but suggested that physicians should consider its use for certain osteoarthritis patients, and that long-term studies should be conducted. Not counting the unpublished, no control group trial by Lawrence, these two articles are the only clinical trial support for MSM for osteoarthritis.
- Seasonal Allergic Rhinitis: Barrager et al. evaluated the efficacy of MSM for hayfever. Twenty-five subjects consumed 2,600 mg of MSM per day for 30 days. The study was not blinded. A significant improvement in symptoms was observed compared to those taking a placebo. No significant changes were observed in two indicators of inflammation (C-reactive protein and immunoglobulin E levels). The authors suggest that MSM is safe for short-term use and recommend that a larger, double-blind study be performed to establish its usefulness in treating symptoms of seasonal allergic rhinitis.
- Interstitial cystitis: In 1978, the FDA approved dimethyl sulfoxide (DMSO) for instillation into the bladder as a treatment for interstitial cystitis. Since DMSO is metabolized to MSM by the body, it is possible that MSM is the active ingredient in DMSO treatments.
- Snoring: Blum & Blum conducted a randomized, double-blind, placebo controlled clinical trial of an MSM-containing throat spray for snoring.
Pharmacology and toxicity
The LD50 (dose at which 50% of test subjects are killed) of MSM is greater than 17.5 grams per kilogram of body weight. In rats, no adverse events were observed after daily doses of 2 g MSM per kg of body weight. In a 90-day follow-up study rats received daily MSM doses of 1.5 g/kg, and no changes were observed in terms of symptoms, blood chemistry, or gross pathology.
Nuclear magnetic resonance (NMR) studies have demonstrated that oral doses of MSM are absorbed into the blood and cross the blood-brain barrier. An NMR study has also found detectable levels of MSM normally present in the blood and cerebrospinal fluid, suggesting that it derives from dietary sources, intestinal bacterial metabolism, and the body's endogenous methanethiol metabolism.
The published clinical trials of MSM did not report any serious side-effects of treatment, but there are no peer-reviewed data on the effects of long-term use in humans.
____________________
| Methylsulfonylmethane |
|
|
IUPAC name
dimethyl sulfone |
Other name
methyl sulfone
methylsulfonylmethane
sulfonylbismethane
DMSO2 |
| Identifiers |
| CAS number |
67-71-0  |
| RTECS number |
PB2785000 |
| SMILES |
CS(C)(=O)=O |
| Properties |
| Molecular formula |
C2H6O2S |
| Molar mass |
94.13 g/mol |
| Appearance |
White crystalline solid |
| Density |
1.45 g/cm3 |
| Melting point |
109 °C, 382 K, 228 °F |
| Boiling point |
238 °C, 511 K, 460 °F |
| Hazards |
| MSDS |
External MSDS |
| S-phrases |
S22 S24/25 |
| NFPA 704 |
|
| Flash point |
143 °C |
| Related compounds |
| Related compounds |
DMSO
dimethyl sulfide dimethyl sulfate
sulfolane |
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
| |
*
________________________
Read the article in Wikipedia with references and links October 14,2010
* Methylsulfonylmethane. (2010, August 11). In Wikipedia,
The Free Encyclopedia. Retrieved 06:42, October 14, 2010, from
http://en.wikipedia.org/w/index.php?title=
Methylsulfonylmethane&oldid=378331546
________________________
Read the article in Wikipedia with references and links Feb 27,2011
** Methylsulfonylmethane. (2011, January 21). In Wikipedia,
The Free Encyclopedia. Retrieved 06:37, February 27, 2011, from
http://en.wikipedia.org/w/index.php?title=
Methylsulfonylmethane&oldid=409204489
________________________
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In accordance with FDA regulation, we do not make any therapeutic claims for any Dietary Supplements in accordance with the Dietary Supplement Health and Education Act.
Information on this website is provided for informational purposes only and is not intended as a substitute for the advice provided by your physicians, health care professional or other professional. You should not use the information on this website for diagnosing or treating any health problem, symptom or disease, prescribing any medication or other treatment, or in place of any other professional advice. This information is not intended to diagnose, treat, cure or prevent any diseases. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. Your discretion is advised.
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