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Unfiltered Beer  para-aminobenzoic acid or (PABA)is a potassium salts used as a drug against fibrotic skin disorders, such as Peyronie's disease. PABA is also used in pill form by sufferers of irritable bowel syndrome.... for fatigue, irritability, depression, weeping eczema (moist eczema), scleroderma, patchy pigment loss in skin (vitiligo), and premature grey hair....  Continued Below

Quality PABA from 'Mother Nature'

Country Life Paba, Time Release, 1000 mg- 60 tab The Best Current Available Price ! Find Out Here Hypoallergenic/Vegetarian/KosherThis product is formulated to release its nutrient over a prolonged period of time.

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Now Foods PABA, 500 mg- 100 caps The Best Current Available Price ! Find Out Here PABA (Para-aminobenzoic Acid) is a non-essential member of the B-vitamin family. We offer a complete line of individual and combination formulas of B-vitamin products.

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Solgar PABA 550 mg, 100 caps The Best Current Available Price ! Find Out Here Solgar PABA 550 mg, 100 caps

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Twinlab PABA, 500 mg- 100 caps The Best Current Available Price ! Find Out Here Paba (Para-Amino Benzoic Acid) may be helpful for eczema, nervous disorders, hyperthyroidism, stress, infertility, and hair color. Instructions: As a dietary supplement, one or more capsules daily. Additional Info: Well tolerated by the most highly allergic individuals. Ingredients: PABA (para-aminobenzoic acid) (pure crystalline)500mg

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Source Naturals PABA 100 mg, 100 tab The Best Current Available Price ! Find Out Here PABA, or para-aminobenzoic acid, is generally classified with the B-vitamin family, although it is not itself a vitamin. Its best known role is as a precursor for folic acid production. Folic acid is important in cell division and the healthy development and structure of red blood cells. Supplement Facts for 100 mg serving size: 1 tablet. Amount %DV PABA (para-Aminobenzoic Acid) 100 mg. Other Ingredients: dibasic calcium phosphate, modified cellulose gum, stearic acid, magnesium stearate and colloidal silicon dioxide. Suggested Use: One tablet daily. Warning: NOTE: If you are pregnant or breastfeeding, consult your health care professional before using this product.

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Source Naturals PABA 100 mg, 250 tab The Best Current Available Price ! Find Out Here PABA, or para-aminobenzoic acid, is generally classified with the B-vitamin family, although it is not itself a vitamin. Its best known role is as a precursor for folic acid production. Folic acid is important in cell division and the healthy development and structure of red blood cells. Supplement Facts for 100 mg serving size: 1 tablet. Amount %DV PABA (para-Aminobenzoic Acid) 100 mg. Other Ingredients: dibasic calcium phosphate, modified cellulose gum, stearic acid, magnesium stearate and colloidal silicon dioxide. Suggested Use: One tablet daily. Warning: NOTE: If you are pregnant or breastfeeding, consult your health care professional before using this product.

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PABA

4-Aminobenzoic acid (also known as para-aminobenzoic acid or PABA) is an organic compound with the formula H2NC6H4CO2H. PABA is a white grey crystalline substance that is only slightly soluble in water. It consists of a benzene ring substituted with an amino group and a carboxyl group.

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Production and occurrence

In industry, PABA is mainly prepared by two routes: reduction of 4-nitrobenzoic acid and theHoffman degradation of the monoamide derived from terephthalic acid.

Food sources of PABA include liver, brewer's yeast (and unfiltered beer), kidney, molasses, and whole grains.

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Biology

Biochemistry

Tetrahydrofolate synthesis pathway

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PABA is an intermediate in the bacterial synthesis of folate. It has been referred to as Vitamin Bx. Some bacteria in the human intestinal tract such as E. coli require PABA. Humans require folate since we lack the enzymes to convert PABA to folate. Therefore, in humans, PABA is not a vitamin and is considered nonessential.

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Sulfonamide drugs are structurally similar to PABA, and their antibacterial activity is due to their ability to interfere with the conversion of PABA to folate by the enzyme dihydropteroate synthetase. Thus, bacterial growth is limited through folate deficiency without effect on human cells.

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Medical use

The potassium salt is used as a drug against fibrotic skin disorders, such as Peyronie's disease, under the trade name Potaba. PABA is also occasionally used in pill form by sufferers of irritable bowel syndrome to treat its associated gastrointestinal symptoms, and in nutritional epidemiological studies to assess the completeness of 24-hour urine collection for the determination of urinary sodium, potassium, or nitrogen levels

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Nutritional supplement

Despite the lack of any recognized syndromes of PABA deficiency in humans, many claims of benefit are made by commercial suppliers of PABA as a nutritional supplement. Benefit is claimed for fatigue, irritability, depression, weeping eczema (moist eczema), scleroderma (premature hardening of skin), patchy pigment loss in skin (vitiligo), and premature grey hair.

Oral supplements of PABA can make the skin less sensitive to sun damage.

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Commercial and industrial use

PABA mainly finds use in the biomedical sector. Other uses include its conversion to specialty azo dyes and crosslinking agents.

In the past, PABA was widely used in sunscreens as a UV filter. It is a UVB absorber, meaning that it can absorb wavelengths between 290-320 nm.  Patented in 1943, PABA was one of the first active ingredients to be used in sunscreen.  The first in vivo studies on mice showed that PABA reduced UV damage. In addition, PABA was shown to protect against skin tumors in rodents.  Animal and in vitro studies in the early 1980's suggested PABA might increase the risk of cellular UV damage. On the basis of these studies as well as problems with allergies and clothing discoloration, PABA fell out of favor as a sunscreen. However, water-insoluble PABA derivatives such as octyl dimethyl PABA (padimate O) are currently used in some products.

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Safety considerations

PABA is largely nontoxic, the median lethal dose of PABA in dogs (oral) is 2 g/kg. Allergic reactions to PABA can occur. PABA is formed in the metabolism of certain ester local anesthetics, and many allergic reactions to local anesthetics are the result of reactions to PABA.

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Tetrahydrofolate synthesis pathway

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4-Aminobenzoic acid
IUPAC name 4-Aminobenzoic acid
Other name para-Aminobenzoic acid; p-Aminobenzoic acid; PABA; Vitamin Bx; Bacterial vitamin H1
Identifiers
CAS number	150-13-0
PubChem	978
ChemSpider	953
UNII	TL2TJE8QTX
SMILES	O=C(O)c1ccc(N)cc1
InChI	1/C7H7NO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,8H2,(H,9,10)
InChI key	ALYNCZNDIQEVRV-UHFFFAOYAH
Properties
Molecular formula	C7H7NO2
Molar mass	137.14 g mol−1
Appearance	White-grey crystals
Density	1.374 g/mL
Melting point	187–189 °C
Solubility in water	1 g/170 mL (25 °C) 1 g/90 mL (90 °C)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)

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Read the Current article in Wikipedia with references and links October 15, 2010

* 4-Aminobenzoic acid. (2010, September 29). In Wikipedia,

The Free Encyclopedia. Retrieved 13:42, October 14, 2010, from

http://en.wikipedia.org/w/index.php?title=

4-Aminobenzoic_acid&oldid=387702434

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