...........Naturally
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Alternative Energy Accessories
..is a neurosteroid. It acts as an anti-inflammatory agent and regulates the immune response. It may affect gum health, increasing risk of gingivitis (gum inflammation) and tooth decay. It appears to prevent endometrial cancer (involving the uterine lining) by regulating the effects of estrogen.... Continued Below |
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Quality Progesterone Cream from 'Mother Nature' |
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What Your Doctor May Not Tell You about Menopause describes the side effects synthetic hormone replacement therapy may have and includes a program of natural alternatives, which can balance hormones naturally, and maintain energy, and sexual vitality, and health for life. The exciting facts about natural progesterone-and how it can deliver what HRT and estrogen only promise. Premenopausal symptoms, endometriosis, weight gain, low sex drive, fibrocystic breasts, heart disease, and osteoporosis-most women will experience these or other hormone-related problems. And today, millions of women concerned about aging must decide whether or not to undergo synthetic hormone replacement therapy- and suffer its side effects and increased risks of cancer. But there is revolutionary news about completely safe, natural progesterone, the only hormone supplement women may need as they age. The exciting clinical findings from its use were first spread by word by mouth, then in a groundbreaking book written by acclaimed California physician John R. Lee. Now, in this expanded and completely updated edition, Dr. Lee brings you lifesaving facts that even your doctor may not know about premarin, provera, and other HRT drugs; gives you and easy-to-follow nonprescription Hormone Balance program; tells you how to stay energized, strong, sexually vigorous, and free from female problems before menopause, during the menopausal years, and beyond. |
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Arthur Andrew Medical Proferia Advanced Dermal Progesterone - 2 oz
Proferia, transdermal progesterone, is safe, natural and does not contain petroleum, lanolin or animal derived substances. |
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Emerita Pro-Gest Progesterone Cream - Paraben Free, 4 oz
Pro-Gest cream is manufactured to contain 450 milligrams (mg) of USP Progesterone per ounce (900 mg per two-ounce tube). Each 1/4 tsp contains approximately 20 mg of USP Progesterone. Careful clinical research has shown this to be an effective amount to achieve a natural balance. |
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Good n' Natural Progesterone Cream, Menopause Formula, 480 mg- 4 oz
During a woman's child-bearing years, estrogen and progesterone are produced by a woman's reproductive system. Each month, through a complex series of signals between the ovaries, hypothalamus, and pituitary gland, an egg is released from the ovaries. This natural process also results in the production of adequate amounts of estrogen and progesterone, which are important for the proper functioning of a woman's body. During the menopausal years, not as much estrogen is produced and progesterone levels decline, sometimes dramatically. This is why many leading women's health care professionals recommend the use of a progesterone cream for perimenopausal and menopausal women. |
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Progesterone Cream |
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Joint Komfort Progesterone Cream - 50 ml
St. Paul Brands(joint Komfort) Natural Progesterone Cream is a natural skin cream that supplies a physiologically correct dose of progesterone into the body to help balance hormone levels in menopausal women. Acting similarly to estrogen, progesterone supports breast and uterine health and helps ease symptoms of menopause such as hot flashes, irritability and poor sleep quality. Natural Progesterone USP from soy can alleviate symptoms related with menopause Advanced liposomal delivery – Very fat-soluble, easily absorbed through the skin. |
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Now Foods Progesterone Cream W/Lavender, 3 oz
...with 20 mg of Natural Progesterone per pump from Wild Yam & Balancing Herbs. No artificial colors, fragrances or parabens. No Animal Testing. Calming Lavender. |
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Progesterone Cream |
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Organic Excellence Natural Progesterone with Phytoestrogens Metered Pump - 3 oz
Natural Progesterone Cream WITH Phytoestrogens is a technologically advanced, light greaseless natural progesterone cream in a hypoallergenic base, non-comedogenic (won't clog pores) aloe vera base, free of added fragrance and artificial colors. Organic Excellence is a proud sponsor of The Progesterone Research Institute, founded by John R. Lee, MD to study physiological effects of Natural Progesterone and increase knowledge of this important hormone. A portion of your purchase price is donated to this research project. All natural and completely chemical free. Organic Excellence Natural Progesterone Cream is in a chemical free base with certified organic herbs, and contains approximately 500 mg of natural progesterone per ounce. Organic Excellence is the only company that formulates its natural progesterone creams (and all of its products) in a chemical free base with certified organic herbs. Suggested Use: Directions For Use: For Each Phase of A Woman's Life, According to Dr. John R. Lee. Use 1/8 -1/4 tsp of cream 2 times per day for: 1. REGULARLY MENSTRUATING WOMEN WITH SYMPTOMS OF ESTROGEN DOMINANCE (See Back Panel): Start using OE-Natural Progesterone Cream on the 12th day of your menstrual cycle, (Day 1 is the day the bleeding begins) until day 26 of your cycle. Repeat this schedule each month. 2. MENSTRUATING WOMEN APPROACHING MENOPAUSE WITH SYMPTOMS OF ESTROGEN DOMINANCE (See Back Panel): Start using OE-Natural Progesterone Cream on the 8th day (Day 1 is the day the bleeding begins), until day 26. Stop on day 26. If you do not begin your period within 7 days from day 26, you may resume applying the cream twice per day. Do not apply the cream for more than 25 consecutive days, without taking a 5-day break. If you begin menstruating during this 25-day interval, stop using the cream, and begin using the cream again on the 8th day-through day 26 3. MENOPAUSAL WOMEN WHO HAVE STOPPED MENSTRUATING (because of age or hysterectomy): Start using OE- Natural Progesterone Cream on the 6th day of each calendar month, and continue until the last day of the calendar month. Then, stop using the cream, and resume using it on the 6th day of the next calendar month. Some women may notice that after a week to two weeks of using their OE-Natural Progesterone Cream, some vaginal spotting may occur due to the reaction of their own estrogen receptors throughout the body. This should stop after a few months, if not, consult your doctor. Natural Progesterone Cream Pump with Phytoestrogens Metered Dose Ingredients: Aloe Vera Gel*, Natural Progesterone USP (micronized USP, derived from the Mexical Wild Yam), Red Clover Leaf Extract (isoflavones, phytoestrogen)*, Evening Primrose (oenothera biennis) oil, Vitamin E (d-Alpha Tocopherol), MSM (Methyl Sulfonyl Methane), Siberian Ginseng*, Burdock Root, Black Cohosh (phytoestrogen), Chamomile*, Milk Thistle Extract*, Shea Butter, Lecithin, Allantoin, Grape Seed Extract, Natural Glycerin, *Certified Organic Herb. WARNINGS: Progesterone. |
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Organic Excellence Natural Progesterone Without Phytoestrogens Cream - 2 oz
Natural Progesterone Cream WITHOUT Phytoestrogens is a technologically advanced, light greaseless natural progesterone cream in a hypoallergenic base, non-comedogenic (won't clog pores) aloe vera base, free of added fragrance and artificial colors. Organic Excellence is a proud sponsor of The Progesterone Research Institute, founded by John R. Lee, MD to study physiological effects of Natural Progesterone and increase knowledge of this important hormone. A portion of your purchase price is donated to this research project. All natural and completely chemical free. Organic Excellence Natural Progesterone Cream is in a chemical free base with certified organic herbs, and contains approximately 500 mg of natural progesterone per ounce. Organic Excellence is the only company that formulates its natural progesterone creams (and all of its products) in a chemical free base with certified organic herbs. Suggested Use: Directions For Use: For Each Phase of A Woman's Life, According to Dr. John R. Lee. Use 1/8 -1/4 tsp of cream 2 times per day for: 1. REGULARLY MENSTRUATING WOMEN WITH SYMPTOMS OF ESTROGEN DOMINANCE (See Back Panel): Start using OE-Natural Progesterone Cream on the 12th day of your menstrual cycle, (Day 1 is the day the bleeding begins) until day 26 of your cycle. Repeat this schedule each month. 2. MENSTRUATING WOMEN APPROACHING MENOPAUSE WITH SYMPTOMS OF ESTROGEN DOMINANCE (See Back Panel): Start using OE-Natural Progesterone Cream on the 8th day (Day 1 is the day the bleeding begins), until day 26. Stop on day 26. If you do not begin your period within 7 days from day 26, you may resume applying the cream twice per day. Do not apply the cream for more than 25 consecutive days, without taking a 5-day break. If you begin menstruating during this 25-day interval, stop using the cream, and begin using the cream again on the 8th day-through day 26. 3. MENOPAUSAL WOMENWHO HAVE STOPPED MENSTRUATING (because of age or hysterectomy):Start using OE- Natural Progesterone Cream on the 6th day of each calendar month, and continue until the last day of the calendar month. Then, stop using the cream, and resume using it on the 6th day of the next calendar month. Some women may notice that after a week to two weeks of using their OE-Natural Progesterone Cream, some vaginal spotting may occur due to the reaction of their own estrogen receptors throughout the body. This should stop after a few months, if not, consult your doctor. Natural Progesterone Cream Pump Metered Dose Ingredients: Aloe Vera Gel*, Avocado Oil, Natural Progesterone (micronized USP, derived from the Mexical Wild Yam), Carrot Oil, Cramp Bark, Dong Quai, Grape Seed Extract, Lemon Grass Oil*, Natural Glycerin, Rosemary Extract*, Chamomile*, Milk Thistle Extract*, Sarsaparilla, Saw palmetto Berries*, Stearic Acid, Vitamin A Palmitate, Vitamin E, *Certified Organic Herb. WARNINGS: Progesterone creams are currently restricted from sale in California as outlined under California's Proposition 65. |
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Progesterone Cream |
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Source Naturals Progesterone Cream, 2 oz
Eternal Woman Progesterone Cream is a natural skin cream that supplies a physiologically correct dose of progesterone into the body to help balance hormone levels in menopausal women. Acting similarly to estrogen, progesterone supports breast and uterine health and helps ease symptoms of menopause such as hot flashes, irritability and poor sleep quality. Maximize Effectiveness with Transdermal Delivery. Eternal Woman Progesterone Cream uses advanced skin penetrating technology to deliver progesterone directly into the bloodstream. Although transdermal delivery of hormones has been widely used, potency can vary depending on the quality of the delivery system. Eternal Woman Progesterone Cream’s unique liposome-mediated delivery system carries the progesterone directly into the bloodstream, bypassing the metabolic processes required by other transdermals, assuring potency. In this process progesterone is absorbed into fat cells beneath the skin, and is gradually taken up by red blood cells and then transported into capillaries passing through the fat to be delivered throughout the body. Eternal Woman Progesterone Cream absorbs within seconds and leaves fresh, clean feeling skin. Guaranteed to contain 500 mg of progesterone per ounce. |
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Wise Essentials Wild Yam and Progesterone Creme Jar - 2 oz
A rich non-comedogenic, hypo-allergenic creme for more severe discomfort during the monthly or midlife changes and protective after the change. Gently rub 1/8 to 1/2 tsp. On clean skin to belly, thighs, wrists, twice daily. Use 1-2 weeks prior to menstruation each month. Non-menstruating women use any 3 weeks each month. Best results with regular use. WARNINGS: Progesterone creams are currently restricted from sale in California as outlined under California's Proposition 65. |
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Quality Progesterone Cream from 'Kalyx' |
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Pro-Gest Natural Progesterone Body Cream 48 (1.3 gm) single use packets: K From "Emerita"
The Original Natural Progesterone Cream® goes paraben-free! Who knew a little tube of cream could change the world? In 1978 we had a revolutionary idea: that there was not enough choice when it came to support for perimenopause and menopause. So we created Pro-Gest to give women a much-deserved alternative. It's the only natural progesterone cream that's been clinically tested. It's the best-selling progesterone cream available anywhere (and has been for many years). USP Progesterone: Pro-Gest cream is manufactured to contain 450 milligrams (mg) of USP Progesterone per ounce (900 mg per two-ounce tube). Each ¼ tsp contains approximately 20 mg of USP Progesterone. Careful clinical research has shown this to be an effective amount to achieve a natural balance. United States Pharmacopoeia (USP) denotes a government recognized standard of purity and strength. It is sometimes referred to as ''human-identical'' or ''bio-identical'' progesterone, which differentiates it from synthetic progestins or progestogens. USP classifies the progesterone as the highest quality available. Key organic and botanical ingredients: Vitamin E, Aloe Vera, Safflower oil, Sweet Almond oil, Orange oil, Lemon peel oil. |
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FemGest Progesterone Cream 2 oz Twin Pack, 4 oz: K From "Home Health"
The Natural Cream for Women. Buy 1 Get 1 Free. Value pack contains 2 ~ 2 oz. (57g) Jars. Home Health's FemGest™ is a progesterone cream designed especially for: Women of childbearing years.* Perimenopausal age women. Menopausal age women. Postmenopausal age women. FemGest™ is an organically based form of progesterone cream designed especially for women of childbearing years, perimenopausal and menopausal aged women and postmenopausal aged women. Our unique formula represents a gentle, holistic approach to your body's need for balance. Using progesterone combined with soothing Aloe Vera gel and Grapefruit extract, FemGest™ is for those times when you want a supportive, soothing cream that harmonizes with your unique nature. FemGest™ - inspired by the natural rhythm of life. Contains No mineral oil. FemGest™ has not been tested on animals. |
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Progesterone Cream |
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Progesta-Care Natural Progesterone Body Cream for Menopause with Cooling Peppermint 4 oz: K
The Best Current Available Price Superior Natural Progesterone Body Cream with Cooling Peppermint. Available in 4 oz. size pre-measured airtight clinical hygienic pumps. One full press of the pump dispenses 20 mg of natural Progesterone USP, the recommended amount by Dr. John R. Lee, making it easy to use with confidence. The pump protects the natural ingredients from oxidation thus, ensuring the potency of the natural Progesterone. Body Function Supported: Progesta-Care contains natural Progesterone USP that is formulated to provide relief from menopausal symptoms, giving millions of women a safe and healthy alternative. Background: Progesterone can direct and control the production of other hormones such as Estrogen. Most significantly, it is know that high amounts of Estrogen can induce a host of metabolic disturbances, and the body's natural way of counterbalancing. Estrogen is with Progesterone. Progesta-Care helps to achieve a natural balance. How to Use: Dispense cream into the palm of the hand and rub onto the skin of your chest, abdomen, inner arms or thighs - rotating area each time. Duration: Menstruating Women: Apply on the 12th day after the first day of the menstrual flow through the 27th day. Menopausal Women: Apply for a maximum of 25 consecutive days. Resume after a five-day break. |
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Quality Progesterone Cream from 'House Of Nutrition' |
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At Last Naturals Equi-Gest Progesterone Cream 2oz
A Natural Balancing Cream for Menopausal Support. Description: During and after Menopause and Perimenopause, women experience a drop in progesterone levels. Lack of progesterone can cause you to feel irritable and depressed. You may experience painful periods, insomnia and vaginal dryness. Regain control of your health with Equigest Cream, a natural external cosmetic progesterone cream from At Last Naturals. Equigest is an external cosmetic progesterone cream you apply to your body. It contains just the right combination of quality ingredients to help maintain a healthy hormonal balance. Why it Works: Equigest is a natural balancing cream that provides PMS, Perimenopausal and Menopausal support through a nourishing formulation of vitamin E, vitamin A and pure aloe vera. Equigest contains USP micronized progesterone (The process of micronization allows for steady, even absorption). *United States Pharmacopoeia (USP) denotes a recognized standard of purity and strength. It is sometimes referred to as "human-identical" or "bio-identical" progesterone, which differentiates it from synthetic progestins or progestogens. USP classifies the progesterone as the highest quality available. How to Use: Equigest offers superior transdermal absorption. To use, simply massage 1/4 to 1/2 teaspoonful of the progesterone cream into the soft parts of the body including the belly, inner thigh and upper arm. Rotate area of application daily for maximum benefit. For best results apply to clean skin two times daily.Individual needs may vary. The following are recommendations that should be confirmed or modified upon consultation with your health care provider. *These are only SUGGESTED uses: For menopausal and non-menstruating women: Apply Equigest cream for a maximum of 21 consecutive days per month. Resume use as needed after 7 days of non-application. For menstruating women: Apply the progesterone cream as directed two weeks prior to the onset of your period. Discontinue use during your period. Warning: Application of our natural balancing cream is intended for external cosmetic use only. If irritation occurs, discontinue use immediately. Consult a health care professional before using our progesterone cream or any product during pregnancy or if you have a serious medical condition. Keep out of reach of children. Store at room temperature. |
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Progesterone Cream |
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Description: Product #: 95135. Size: 2oz Cream Directions: Apply 1/4 tsp. (about the size of a thumbnail) to desired area up to 2 times daily. Do not exceed 2 oz. of this product applied topically per month. Serving Size: 1 Cream. Ingredients: Amount per serving: % Daily Value: + Carbomer ~ Cetyl Esters ~ Evening Primrose Oil ~ Fragrance ~ Isopropyl Myristate ~ Isostearic Acid ~ Jojoba Oil ~ Lecithin ~ Methylparaben ~ Phenoxyethanol ~ Phenylalanine ~ Polysorbate 80 ~ Progesterone (USP Grade) ~ Propylparaben ~ Purified Water ~ Sweet Almond Oil ~ Tocopheryl Acetate ~ Key to Ingredients: ~ = Daily Value not established. + = Percent Daily Value is based on a 2,000 calorie diet. † = Values differ depending on age ‡ = Values differ depending on age. Other Ingredients: Other: See product label for more information. |
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Kal's Progesterone Cream Fragrance 4oz
Description: Fragrance Free, 500 mg, Pure Progesterone per Ounce (2000 mg per bottle) USP Grade Progesterone - Stable, Liposomal Preparation for Enhanced Skin Therapy Product #: 10028. Size: 4oz Cream. Directions: Apply 1.4 tsp. (about the size of a thumbnail) to desired area up to 2 times daily. Do not use for more than 3 weeks out of a month. Do not exceed 2 oz. of this product topically per month. Serving Size: 1 Cream. Ingredients: Amount per serving: % Daily Value: + Caprylic Acid ~ Cetearyl Glucoside ~ Glycerine ~ Glyceryl Stearate ~ Glycine ~ Grapeseed Oil ~ Lecithin ~ Methylparaben ~ Progesterone (USP Grade) ~ Propylparaben ~ Sunflower Oil ~ Tocopherol ~ Water ~ Xanthan Gum ~ Key to Ingredients: ~ = Daily Value not established. + = Percent Daily Value is based on a 2,000 calorie diet. † = Values differ depending on age ‡ = Values differ depending on age. Other Ingredients: Other: See product label for more information. |
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Karuna Corporation's Progesterone Pure Cream 30 mg 2 oz
Progesterone Pure Cream 2 oz. This item is not available for shipment to Canada or Norway. This product is not labeled for sale in the State of California. California residents can order product PRO38. Hypoallergenic Premium Natural Progesterone Cream for Men and Women. Supplement Facts: Serving Size: 1/4 tsp. Servings per container: 48. Progesterone per serving: 30 mg. Ingredients per 2 oz. tube: Purified Water, Jojoba Oil, Whole Leaf Aloe Vera Extract, Shea Butter, Cetyl Alcohol (coconut oil derived), Micronized USP Progesterone (wild yam derived) 1440 mg, Stearic Acid (palm kernel derived thickener), Monosodium Salt, Disodium Edetate (plant derived preservative), Grapefruit Seed Extract, Potassium Sorbate, Vitamin E, Xanthan Gum (seaweed derived thickener). Apply as directed in the enclosed educational brochure. Also enclosed: tsp measuring spoon. Intended for external cosmetic use. Consult your doctor if you have a medical condition, if you are or may become pregnant, or if you are nursing. Keep out of the reach of children. Store at room temperature. Hypoallergenic, fragrance-free, paraben-free, no animal products, no mineral oil, no artificial colors, no artificial preservatives, not tested on animals. Optimal transdermal delivery verified by assay and user testing. Absorbs quickly with no sticky residue. Hypoallergenic and fragrance-free. Highest quality ingredients and exacting production standards. Physician-verified and recommended. A pure, light moisturizing cream with Micronized USP Progesterone in the amounts recommended by leading authorities. Karuna Corporation has provided exceptional nutritional therapeutics to healthcare professionals and their patients since 1981. No finer product of this type is available anywhere at any price. 100% Satisfaction Guarantee-If for any reason you are not completely satisfied your money will be cheerfully refunded. All information is intended for educational purposes only. It has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent disease. |
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Progesterone Cream |
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Life Link's Progesterone Cream 100mg (57gm) 2oz
About Progesterone Cream: As people age, their bodies hormone production falls. In women, progesterone levels fall far more than do estradiol levels, producing a hormonal state that contributes to such unpleasant problems as PMS, hot flashes, night sweats, osteoporosis, endometriosis, fibrocystic breast disease, anovulation, vaginal dryness, menstrual migraine, depression, and mood swings. Progesterone supplementation is widely used for these conditions as well as for reducing risk of breast cancer during estrogen therapy (as in HRT or breast enhancement). The bioavailability of progesterone is many times greater when applied to the skin (topically) than when taken orally. Topical application causes a significant rise in progesterone levels in the blood and other tissues. Penetration efficiency varies from person to person and depends upon where on the body it is applied, breasts and underarms absorb best. A typical dosage is 1/4 to 1/2 tsp per day, but may need adjustment for optimal results. This product is made from pure crystalline progesterone, identical in molecular structure to the progesterone made by your body. |
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Now's Progesterone Cream Liposomal Lotion 3oz
Progesterone is a safe, natural alternative to HRT because it's produced by a woman's body during the second half of each monthly cycle, from ovulation until menses, and is the dominant hormone during this phase. Servings per container: 3 oz. Suggested Use: 1 full press dispenses the recommended 20 mg of USP Progesterone. Rotate application between abdomen, hands and thighs for best results. FOR MENSTRUATING (OVULATING) AND PERIMENOPAUSAL WOMEN: Use 1X or 2X daily or as needed, starting on the 7th day after the 1st day of menstrual flow through the 27th day. MENOPAUSAL OR NON-MENSTRUATING WOMEN: Apply 1X or 2X daily for a maximum of 25 days. Resume after a 5-day break or as directed by a health practitioner. Other Ingredients: Purified Water, Aloe Vera ( Aloe barbadensis ) (Juice from Leaves), Stearyl Alcohol, Ceteareth-20, Avocado Oil (Persea gratissima), Stearic Acid, Glycerin, Progesterone (Micronized and USP Grade), Phospholipids (from Lecithin), Natural Vitamin E (as d-alpha-Tocopherol), Vitamin A (as Retinyl Palmitate), Vitamin B-5 (as Panthenol), Herbal Extract Blend of: Grape Seed, Sarsaparilla Root ( Smilax officinalis syn. S. regelii ), Rosemary Leaf ( Rosmarinus officinalis ), Dong Quai Root ( Angelica polymorpha var. sinensis ), Saw Palmetto Berries ( Serenoa repens ), Wild Yam Rhizome/Root ( Dioscorea villosa ), Comfrey Root ( Symphytum officinale ), Chamomille Flower ( Matricaria recutita ), Carrot Oil ( Daucua carota sativa ), Lemon Grass Oil ( Cymbopogon citratus ) and Xanthan Gum ( Xanthomonas campestris ). Warnings: Please discontinue use if irritation or red skin develops, and consult a dermatologist. Please do not buy this product if the inner seal is broken. Store in a cool, dry and dark place after opening. Disclaimers: None. |
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Progesterone Cream |
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Physiologic's Progesterone Cream 4 oz
Progesterone Cream 4 oz.This item is not available for shipment to Canada or Norway. Ingredients: Purified Water, Aloe Vera Gel, Petrolatum, Tocopheryl Acetate (Vitamin E), Cetearyl Alcohol and Ceteareth-20, Glyceryl Stearate, C12-15 Alkyl Benzoate, Stearic Acid, Cetyl Alcohol, Glycerin, Progesterone, Triethanolamine, Polysorbate 80, Keratin Amino Acids, Diazolidinyl Urea, Carbomer, Coconut Oil, Almond Oil, Grapefruit Seed Extract (Citrus grandis), Methylparaben, BHA, Lemon Oil (Citrus medica limonum), Propylparaben, Panthenol, Sodium Hyaluronate. Contains: 480 mg of USP Progestserone per ounce. Suggested use: For best results, massage to teaspoon of the cream into your hands and body, one (1) to two (2) times daily. Apply for 21 days and discontinue use for 7 days, then repeat, or follow the advice of your health care professional. Warning: This product contains a chemical known to the state of California to cause cancer. Note: Pregnant or nursing woman should consult a doctor before using any product. Consult doctor before use if you have, or have had, a medical condition or liver disease. Discontinue use and consult your doctor if any adverse reactions occur, including acne or vaginal spotting or bleeding. Do not apply to the same skin area as other skin products. NOT INTENDED FOR USE BY PERSONS UNDER THE AGE OF 18. FOR EXTENAL USE ONLY.KEEP OUT OF REACH OF CHILDREN. AVOID CONTACT WITH EYES. |
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Protocol For Life Balance Progesterone Cream 3 oz The Best Current Available Price ! Protocol For Life Balance Progesterone Cream 3 oz. |
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Source Naturals Progesterone Cream in Tube 4oz
Progesterone Cream Advanced Liposomal Delivery. Eternal Woman Progesterone Cream features progesterone from healthful, woman-friendly soy, enhanced by Mexican wild yam. Progesterone Cream can help address normal menopausal discomforts, such as hot flashes, night sweats, and irritability. Eternal Woman Progesterone Cream is guaranteed to contain 500 mg of progesterone per ounce.Eternal Woman Progesterone Cream - For Women of All Ages. Source Naturals Progesterone Cream is the first progesterone cream to utilize unique liposomal delivery of key ingredients. Liposomes are micro-penetrating lipid spheres made from lecithin, which pass through skin layers more easily than non-liposomal creams. Progesterone Cream features natural progesterone from healthful soy. Unlike creams which don't divulge their progesterone content, Progesterone Cream is guaranteed to contain 500 mg of progesterone per ounce! This pure white cream softens and smoothes the skin. Along with natural progesterone, it features aloe vera, Mexican wild yam extract, natural vitamin E, lecithin phospholipid, jojoba oil, and extracts of sage, black cohosh root, ginseng, marigold and grapefruit seed. Rosemary oil is added as a fragrance. Source Naturals Progesterone Cream is part of the Eternal Woman line of products and is suitable for women of all ages. Progesterone Cream Tube Supplement Facts: Serving Size: 1/4 teaspoon. Amount %DVDeionized Water, Aloe Vera Gel, Cetearyl Glucoside, Caprylic/Capric Triglyceride, Cetyl Alcohol, Glycerin, Natural Progesterone USP from soy (500 mg per ounce), Wild Yam Extract, Tocopheryl Acetate (Natural Vitamin E), Lecithin Phospholipid, Glyceryl Stearate & Peg-100 Stearate, Jojoba Oil, Squalene, Benzyl Alcohol, Stearic Acid, Grapefruit Seed Extract, Ginseng Root Extract, Methylparaben, Propylparaben, Sorbic Acid, Xanthan Gum, and Rosemary Oil. Progesterone Cream Suggested Use: Massage 1/4 to 1/2 teaspoon of Progesterone Cream twice daily into smooth skin areas, such as wrists, face, throat, abdomen or chest. Pre-menopausal women use for 14 days prior to the first day of menstruation, discontinue and repeat. Menopausal and postmenopausal women use for 21 days, discontinue for 7 days and repeat. These are general recommendations only and may need to be modified for individual needs. Warning: If you are pregnant, nursing, or intending to become pregnant, consult with a health care professional before using Progesterone Cream. If irritation occurs, discontinue use. Progesterone Cream is for external use only. Do not use around eye area. |
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Progesterone Cream
Progesterone also known as P4 (pregn-4-ene-3,20-dione) is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy (supports gestation) and embryogenesis of humans and other species. Progesterone belongs to a class of hormones called progestogens, and is the major naturally occurring human progestogen.
Progesterone is commonly manufactured from the yam family, Dioscorea. Dioscorea produces large amounts of a steroid called diosgenin, which can be converted into progesterone in the laboratory.
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Chemistry
Progesterone was independently discovered by four research groups.
Willard Myron Allen co-discovered progesterone with his anatomy professor George Washington Corner at the University of Rochester Medical School in 1933. Allen first determined its melting point, molecular weight, and partial molecular structure. He also gave it the name Progesteronederived from Progestational Steroidal ketone.
Like other steroids, progesterone consists of four interconnected cyclic hydrocarbons. Progesterone contains ketone and oxygenated functional groups, as well as two methyl branches. Like all steroid hormones, it is hydrophobic.
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Sources
Animal
Progesterone is produced in the ovaries (to be specific, after ovulation in the corpus luteum), the adrenal glands (near the kidney), and, during pregnancy, in the placenta. Progesterone is also stored in adipose (fat) tissue.
In humans, increasing amounts of progesterone are produced during pregnancy:
- At first, the source is the corpus luteum that has been "rescued" by the presence of human chorionic gonadotropins (hCG) from the conceptus.
- However, after the 8th week, production of progesterone shifts to the placenta. The placenta utilizes maternal cholesterol as the initial substrate, and most of the produced progesterone enters the maternal circulation, but some is picked up by the fetal circulation and used as substrate for fetal corticosteroids. At term the placenta produces about 250 mg progesterone per day.
- An additional source of progesterone is milk products. They contain much progesterone because on dairy farms cows are milked during pregnancy, when the progesterone content of the milk is high. After consumption of milk products the level of bioavailable progesterone goes up.
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Plants
In at least one plant, Juglans regia, progesterone has been detected. In addition, progesterone-like steroids are found in Dioscorea mexican. Dioscorea mexicana is a plant that is part of the yam family native to Mexico. It contains a steroid called diosgenin that is taken from the plant and is converted into progesterone. Diosgenin and progesterone are found in other Dioscorea species as well.
Another plant that contains substances readily convertible to progesterone is Dioscorea pseudojaponica native to Taiwan. Research has shown that the Taiwanese yam contains saponins — steroids that can be converted to diosgenin and thence to progesterone.
Many other Dioscorea species of the yam family contain steroidal substances from which progesterone can be produced. Among the more notable of these are Dioscorea villosa and Dioscorea polygonoides. One study showed that the Dioscorea villosa contains 3.5% diosgenin. Dioscorea polygonoides has been found to contain 2.64% diosgenin as shown by gas chromatography-mass spectrometry. Many of the Dioscorea species that originate from the yam family grow in countries that have tropical and subtropical climates.
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Synthesis
Biosynthesis
In mammals, progesterone (6), like all other steroid hormones, is synthesized from pregnenolone (3), which in turn is derived from cholesterol (1) (see the upper half of the figure to the right).
Cholesterol (1) undergoes double oxidation to produce 20,22-dihydroxycholesterol (2). This vicinal diol is then further oxidized with loss of the side chain starting at position C-22 to produce pregnenolone (3). This reaction is catalyzed by cytochrome P450scc. The conversion of pregnenolone to progesterone takes place in two steps. First, the 3-hydroxyl group is oxidized to a keto group (4) and second, the double bond is moved to C-4, from C-5 through a keto/enol tautomerization reaction. This reaction is catalyzed by 3beta-hydroxysteroid dehydrogenase/delta(5)-delta(4)isomerase.
Progesterone in turn (see lower half of figure to the right) is the precursor of the mineralocorticoid aldosterone, and after conversion to 17-hydroxyprogesterone (another natural progestogen) of cortisol and androstenedione. Androstenedione can be converted to testosterone, estrone and estradiol.
Pregenolone and progesterone can also be synthesized by yeast.
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Laboratory
The Marker semisynthesis of progesterone from diosgenin.
An economical semisynthesis of progesterone from the plant steroid diosgenin isolated from yams was developed by Russell Marker in 1940 for the Parke-Davis pharmaceutical company (see figure to the right). This synthesis is known as the Marker degradation. Additional semisyntheses of progesterone have also been reported starting from a variety of steroids. For the example, cortisone can be simultaneously deoxygenated at the C-17 and C-21 position by treatment with iodotrimethylsilane in chloroform to produce 11-keto-progesterone (ketogestin), which in turn can be reduced at position-11 to yield progesterone
The Johnson total synthesis of progesterone.
A total synthesis of progesterone was reported in 1971 by W.S. Johnson (see figure above). The synthesis begins with reacting the phosphonium salt 7 with phenyl lithium to produce the phosphonium ylide 8. The ylide 8 is reacted with an aldehyde to produce the alkene 9. The ketal protecting groups of 9 are hydrolyzed to produce the diketone 10, which in turn is cyclized to from the cyclopentenone 11. The ketone of 11 is reacted with methyl lithium to yield the tertiary alcohol 12, which in turn is treated with acid to produce the tertiary cation 13. The key step of the synthesis is the π-cation cyclization of 13 in which the B-, C-, and D-rings of the steroid are simultaneously formed to produce 14. This step resembles the cationic cyclization reaction used in the biosynthesis of steroids and hence is referred to asbiomimetic. In the next step the enol orthoester is hydrolyzed to produce the ketone15. The cyclopentene A-ring is then opened by oxidizing with ozone to produce 16. Finally, the diketone 17 undergoes an intramolecular aldol condensation by treating with aqueous potassium hydroxide to produce progesterone
Levels
Progesterone levels (black line) during the menstrual cycle
In women, progesterone levels are relatively low during the preovulatory phase of the menstrual cycle, rise after ovulation, and are elevated during the luteal phase. Progesterone levels tend to be < 2 ng/ml prior to ovulation, and > 5 ng/ml after ovulation. If pregnancy occurs, progesterone levels are initially maintained at luteal levels. With the onset of the luteal-placental shift in progesterone support of the pregnancy, levels start to rise further and may reach 100-200 ng/ml at term. Whether a decrease in progesterone levels is critical for the initiation of labor has been argued and may be species-specific. After delivery of the placenta and during lactation, progesterone levels are very low.
Progesterone levels are relatively low in children and postmenopausal women. Adult males have levels similar to those in women during the follicular phase of the menstrual cycle.
Progesterone exerts its primary action through the intracellular progesterone receptor although a distinct, membrane bound progesterone receptor has also been postulated. In addition, progesterone is a highly potent antagonist of the mineralocorticoid receptor (MR, the receptor for aldosterone and other mineralocorticosteroids). It prevents MR activation by binding to this receptor with an affinity exceeding even those of aldosterone and other corticosteroids such as cortisol and corticosterone.
Progesterone has a number of physiological effects that are amplified in the presence of estrogen. Estrogen through estrogen receptors upregulates the expression of progesterone receptors. Also, elevated levels of progesterone potently reduce the sodium-retaining activity of aldosterone, resulting in natriuresis and a reduction in extracellular fluid volume. Progesterone withdrawal, on the other hand, is associated with a temporary increase in sodium retention (reduced natriuresis, with an increase in extracellular fluid volume) due to the compensatory increase in aldosterone production, which combats the blockade of the mineralocorticoid receptor by the previously elevated level of progesterone
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Reproductive system
Progesterone has key effects via non-genomic signalling on human sperm as they migrate through the female tract before fertilisation occurs, though the receptor(s) as yet remain unidentified. Detailed characterisation of the events occurring in sperm in response to progesterone has elucidated certain events including intracellular calcium transients and maintained changes, slow calcium oscillations, now thought to possibly regulate motility. Interestingly progesterone has also been shown to demonstrate effects on octopus spermatozoa.
Progesterone is sometimes called the "hormone of pregnancy", and it has many roles relating to the development of the fetus:
- Progesterone converts the endometrium to its secretory stage to prepare the uterus for implantation. At the same time progesterone affects the vaginal epithelium and cervical mucus, making it thick and impenetrable to sperm. If pregnancy does not occur, progesterone levels will decrease, leading, in the human, to menstruation. Normal menstrual bleeding is progesterone-withdrawal bleeding.
- During implantation and gestation, progesterone appears to decrease the maternal immune response to allow for the acceptance of the pregnancy.
- Progesterone decreases contractility of the uterine smooth muscle.
- In addition progesterone inhibits lactation during pregnancy. The fall in progesterone levels following delivery is one of the triggers for milk production.
- A drop in progesterone levels is possibly one step that facilitates the onset of labor.
The fetus metabolizes placental progesterone in the production of adrenal steroids.
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Nervous system
Progesterone, like pregnenolone and dehydroepiandrosterone, belongs to the group of neurosteroids. It can be synthesized within the central nervous system and also serves as a precursor to another major neurosteroid, allopregnanolone.
Neurosteroids affect synaptic functioning, are neuroprotective, and affect myelination. They are investigated for their potential to improve memory and cognitive ability. Progesterone affects regulation of apoptotic genes.
Its effect as a neurosteroid works predominantly through the GSK-3 beta pathway, as an inhibitor. (Other GSK-3 beta inhibitors include bipolar mood stabilizers, lithium and valproic acid.)
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Other systems
- It raises epidermal growth factor-1 levels, a factor often used to induce proliferation, and used to sustain cultures, of stem cells.
- It increases core temperature (thermogenic function) during ovulation.
- It reduces spasm and relaxes smooth muscle. Bronchi are widened and mucus regulated. (Progesterone receptors are widely present in submucosal tissue.)
- It acts as an antiinflammatory agent and regulates the immune response.
- It reduces gall-bladder activity.
- It normalizes blood clotting and vascular tone, zinc and copper levels, cell oxygen levels, and use of fat stores for energy.
- It may affect gum health, increasing risk of gingivitis (gum inflammation) and tooth decay.
- It appears to prevent endometrial cancer (involving the uterine lining) by regulating the effects of estrogen.
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Adverse effects
Pill form of progesterone (actually a synthetic version such as Progestogen) taken at 400 mg as cited by the following patent can cause increased fluid retention, which may result in epilepsy, migraine, asthma, cardiac or renal dysfunction. Blood clots that can result in strokes and heart attacks, which may lead to death or long-term disability, may develop; pulmonary embolus or breast cancer can also develop as a result of progesterone therapy. Progesterone is associated with an increased risk of thrombotic disorders such as thrombophlebitis, cerebrovascular disorders, pulmonary embolism, and retinal thrombosis.
Common adverse effects include cramps, abdominal pain, skeletal pain, perineal pain, headache, arthralgia, constipation, dyspareunia, nocturia, diarrhea, nausea, vomiting, breast enlargement, joint pain, flatulence, hot flushes, decreased libido, thirst, increased appetite, nervousness, drowsiness, excessive urination at night. Psychiatric effects including depression, mood swings, emotional instability, aggression, abnormal crying, insomnia, forgetfulness, sleep disorders.
Less frequent adverse effects that may occur include allergy, anemia, bloating, fatigue, tremor, urticaria, pain, conjunctivitis, dizziness, vomiting, myalgia, back pain, breast pain, genital itching, genital yeast infection, upper respiratory tract infection, cystitis, dysuria, asthenia, xerophthalmia, syncope, dysmenorrhea, premenstrual tension, gastritis, urinary tract infection, vaginal discharge, pharyngitis, sweating, hyperventilation, vaginal dryness, dyspnea, fever, edema, flu-like symptoms, dry mouth, rhinitis, leg pain, skin discoloration, skin disorders, seborrhea, sinusitis, acne.
Current research suggests that progesterone plays an important role in the signaling of insulin release and pancreatic function, and may affect the susceptibility to diabetes. It has been shown that women with high levels of progesterone during pregnancy are more likely to develop glucose abnormalities.
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Medical applications
The use of progesterone and its analogues have many medical applications, both to address acute situations and to address the long-term decline of natural progesterone levels. Because of the poor bioavailability of progesterone when taken orally, many synthetic progestins have been designed with improved oral bioavailability. Progesteone was approved by the United States Food and Drug Administration as vaginal gel on July 31, 1997, an oral capsule on May 14, 1998 in an injection form on April 25, 2001 and as a vaginal insert on June 21, 2007.
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Bioavailability
The route of administration impacts the affect of the drug. Give orally, progesterone has a wide person-to-person variability in absorption and bioavailability while synthetic progestins are rapidly absorbed with a longer half-life than progesterone and maintain stable levels in the blood.
Progesterone does not dissolve in water and is poorly absorbed when taken orally unless micronized in oil. Products are often sold as capsules containing micronised progesterone in oil. Progesterone can also be administered through vaginal or rectal suppositories or pessaries, transdermally through a gel or cream, or via injection (though the latter has a short half-life requiring daily administration).
"Natural progesterone" products derived from yams, do not require a prescription but there is no evidence the human body can convert its active ingredient (diosgenin, the plant steroid that is chemically converted to produce progesterone industrially) into progesterone.
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Specific uses
- Progesterone is used to support pregnancy in Assisted Reproductive Technology (ART) cycles such as In-vitro Fertilization (IVF). While daily intramuscular injections of progesterone-in-oil (PIO) have been the standard route of administration, PIO injections are not FDA-approved for use in pregnancy. A recent meta-analysis showed that the intravaginal route with an appropriate dose and dosing frequency is equivalent to daily intramuscular injections. In addition, a recent case-matched study comparing vaginal progesterone with PIO injections showed that live birth rates were nearly identical with both methods.
- Progesterone is used to control anovulatory bleeding. It is also used to prepare uterine lining in infertility therapy and to support early pregnancy. Patients with recurrent pregnancy loss due to inadequate progesterone production may receive progesterone.
- Progesterone is being investigated as potentially beneficial in treating multiple sclerosis, since the characteristic deterioration of nerve myelin insulation halts during pregnancy, when progesterone levels are raised; deterioration commences again when the levels drop.
- Vaginally dosed progesterone is being investigated as potentially beneficial in preventing preterm birth in women at risk for preterm birth. The initial study by Fonseca suggested that vaginal progesterone could prevent preterm birth in women with a history of preterm birth.
A subsequent and larger study showed that vaginal progesterone was no better than placebo in preventing recurrent preterm birth in women with a history of a previous preterm birth, but a planned secondary analysis of the data in this trial showed that women with a short cervix at baseline in the trial had benefit in two ways: a reduction in births less than 32 weeks and a reduction in both the frequency and the time their babies were in intensive care. In another trial, vaginal progesterone was shown to be better than placebo in reducing preterm birth prior to 34 weeks in women with an extremely short cervix at baseline. An editorial by Roberto Romero discusses the role of sonographic cervical length in identifying patients who may benefit from progesterone treatment.
- Progesterone is used in hormone therapy for male to female transsexuals and other women with intersex conditions - especially when synthetic progestins have been ineffective or caused side-effects - since normal breast tissue cannot develop except in the presence of both progestogen and estrogen. Mammary glandular tissue is otherwise fibrotic, the breast shape conical and the areola immature. Progesterone can correct those even after years of inadequate hormonal treatment. Research usually cited against such value was conducted using Provera, a synthetic progestin. Progesterone also has a role in skin elasticity and bone strength, in respiration, in nerve tissue and in female sexuality, and the presence of progesterone receptors in certain muscle and fat tissue may hint at a role in sexually-dimorphic proportions of those.
- Progesterone receptor antagonists, or selective progesterone receptor modulators (SPRM)s, such as RU-486 (Mifepristone), can be used to prevent conception or induce medical abortions.
Note that methods of hormonal contraception do not contain progesterone but a progestin.
Progesterone may affect male behavior.
Progesterone is starting to be used in the treatment of the skin condition hidradenitis suppurativa.
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Aging
Since most progesterone in males is created during testicular production of testosterone, and most in females by the ovaries, the shutting down (whether by natural or chemical means), or removal, of those inevitably causes a considerable reduction in progesterone levels. Previous concentration upon the role of progestagens (progesterone and molecules with similar effects) in female reproduction, when progesterone was simply considered a "female hormone", obscured the significance of progesterone elsewhere in both sexes.
The tendency for progesterone to have a regulatory effect, the presence of progesterone receptors in many types of body tissue, and the pattern of deterioration (or tumor formation) in many of those increasing in later years when progesterone levels have dropped, is prompting widespread research into the potential value of maintaining progesterone levels in both males and females.
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Brain damage
Previous studies have shown that progesterone supports the normal development of neurons in the brain, and that the hormone has a protective effect on damaged brain tissue. It has been observed in animal models that females have reduced susceptibility to traumatic brain injury and this protective effect has been hypothesized to be caused by increased circulating levels of estrogen and progesterone in females. A number of additional animal studies have confirmed that progesterone has neuroprotective effects when administered shortly after traumatic brain injury. Encouraging results have also been reported in human clinical trials.
The mechanism of progesterone protective effects may be the reduction of inflammation that follows brain trauma
*
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|
|---|---|
 |
|
| Systematic (IUPAC) name | |
| pregn-4-ene-3,20-dione | |
| Identifiers | |
| CAS number | 57-83-0 |
| ATC code | G03DA04 |
| PubChem | CID 5994 |
| IUPHAR ligand ID | 2377 |
| DrugBank | DB00396 |
| Chemical data | |
| Formula | C21H30O2 |
| Mol. mass | 314.46 |
| Synonyms | 4-pregnene-3,20-dione |
| Physical data | |
| Melt. point | 126 °C (259 °F) |
| Spec. rot | [α]D |
| Pharmacokinetic data | |
| Bioavailability | prolonged absorption, half-life approx 25-50 hours |
| Protein binding | 96%-99% |
| Metabolism | hepatic to pregnanediols and pregnanolones |
| Half-life | 34.8-55.13 hours |
| Excretion | renal |
| Therapeutic considerations | |
| Pregnancy cat. | B (USA) |
| Legal status | |
| Routes | oral, implant |
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|
*
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Read the article in Wikipedia with references and links October 14, 2010
* Progesterone. (2010, October 8). In Wikipedia,
The Free Encyclopedia. Retrieved 18:01, October 14, 2010, from
http://en.wikipedia.org/w/index.php?title=
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