...is necessary for normal skeletal muscle functioning. Studies have shown that taurine can influence (and possibly reverse) defects in nerve blood flow, motor nerve conduction velocity, and nerve sensory thresholds in experimental diabetic neuropathic rats...  Continued Below

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BlueBonnet's Taurine 500 mg 50Vcaps The Best Current Available Price ! Find Out Here Taurine is a sulfur containing amino acid chemically known as beta-aminoethanesulfonic acid. Taurine is a metabolite of the amino acids methionine and cysteine and is found in most cells. As an antioxidant, taurine is used to quench hypochlorite secreted by leukocyte immune cells. Taurine also aids in osmoregulation (maintenance of proper concentrations of ions) inside the cell. Taurine’s other biological functions include cellular growth, membrane stabilization, sperm motility, bile acid conjugation and neurotransmission. Taurine may also benefit athletic performance as it acts as an insulin mimetic, thereby allowing for better glucose deposition into muscles....

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Life Extension's Taurine 1000mg 50Caps The Best Current Available Price ! Find Out Here Taurine is a sulfur containing amino acid chemically known as beta-aminoethanesulfonic acid. Taurine is a metabolite of the amino acids methionine and cysteine and is found in most cells. As an antioxidant, taurine is used to quench hypochlorite secreted by leukocyte immune cells. Taurine also aids in osmoregulation (maintenance of proper concentrations of ions) inside the cell. Taurine’s other biological functions include cellular growth, membrane stabilization, sperm motility, bile acid conjugation and neurotransmission. Taurine may also benefit athletic performance as it acts as an insulin mimetic, thereby allowing for better glucose deposition into muscles....

Life Extension's L-Taurine Powder 300gm The Best Current Available Price ! Find Out Here Taurine is a sulfur containing amino acid chemically known as beta-aminoethanesulfonic acid. Taurine is a metabolite of the amino acids methionine and cysteine and is found in most cells. As an antioxidant, taurine is used to quench hypochlorite secreted by leukocyte immune cells. Taurine also aids in osmoregulation (maintenance of proper concentrations of ions) inside the cell. Taurine’s other biological functions include cellular growth, membrane stabilization, sperm motility, bile acid conjugation and neurotransmission. Taurine may also benefit athletic performance as it acts as an insulin mimetic, thereby allowing for better glucose deposition into muscles....

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Life Link's Taurine 750mg 100Caps The Best Current Available Price ! Find Out Here Taurine is a sulfur-containing amino acid that is not utilized in protein synthesis, but rather is normally found in the body as simple free molecules. It is a ‘conditionally-essential’ amino acid inasmuch as the body synthesizes too little of it to consistently meet the body’s needs for it — therefore, a dietary source is required in order to avoid deficiency diseases. What we can’t tell you In the U.S. and some other industrialized countries, government agencies like the U.S. Food and Drug Administration have adopted censorship as a method for intensifying their control over the supplement industry and its customers. Thus, FDA regulations prohibit us from telling you that any of our products are effective as medical treatments, even if they are, in fact, effective. Accordingly, we will limit our discussion of L-taurine to a brief summary of recent taurine research, and let you draw your own conclusions about what medical conditions it may be effective in treating. Taurine is involved in a variety of different physiological processes, including:the conversion of metabolic wastes into water-soluble salts regulation of calcium ion flux across membranes membrane stabilization detoxification of pro-oxidants such as hypochlorous acid and chloro-carbons normal development of fetal tissues. Taurine deficiencies occur in various mammals, including humans and cats. During pregnancy, taurine deficiency in the mother leads to retarded growth of the offspring, and to impaired development of the central nervous system and of the pancreatic insulin-producing structures. The adult offspring of taurine-deficient mothers have impaired glucose tolerance, impaired neurological function, and vascular dysfunction; they may develop gestational diabetes and transmit these defects to the next generation. In adult humans, taurine has been used with varying degrees of success to treat a wide variety of conditions, including: cardiovascular diseases, hypercholesterolemia, epilepsy and other seizure disorders, macular degeneration, Alzheimer’s disease, hepatic disorders, alcoholism, and cystic fibrosis. In cats, taurine is used mainly for preventing deficiency diseases: retinal degeneration, cardiomyopathy, altered white-cell function, and abnormal growth and development. Cardiovascular effects Oral taurine treatment has been studied extensively as an agent for lowering high blood pressure. Its beneficial effects have been demonstrated both in rats and in humans. In human subjects suffering essential hypertension, taurine supplementation at 6 g/day for as little as 7 days resulted in measurable decreases in blood pressure. It has been known for more than 20 years that taurine supplementation improves the function of the heart in people with congestive heart failure (a weakness of the heart muscle). The medical world, however, has shown very little interest in this treatment, preferring instead to treat with expensive prescription drugs....

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Taurine

From an article in Wikipedia Mar 6, 2009

Taurine, or 2-aminoethanesulfonic acid, is an organic acid.

It is also a major constituent of bile and can be found in the lower intestine and in small amounts in the tissues of many animals and in humans as well.

Taurine is a derivative of the sulfur-containing (sulfhydryl) amino acid, cysteine.

Taurine is one of the few known naturally occurring sulfonic acids.

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Taurine is named after the Latin taurus, which means bull or ox, as it was first isolated from ox bile in 1827 by German scientists Friedrich Tiedemann and Leopold Gmelin.

It is often called an amino acid, even in scientific literature,but as it lacks a carboxyl group it is not strictly an amino acid.

It does contain a sulfonate group and may be called an amino sulfonic acid.

Small polypeptides have been identified which contain taurine, but to date no aminoacyl tRNA synthetase has been identified as specifically recognizing taurine and capable of incorporating it onto a tRNA.

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Biosynthesis

The major pathway for mammalian taurine synthesis occurs in the pancrease via the cysteine sulfinic acid pathway.

In this pathway, the sulfhydryl group of cysteine is first oxidized to cysteine sulfinic acid by the enzyme cysteine dioxygenase.

Cysteine sulfinic acid, in turn, is decarboxylated by sulfinoalanine decarboxylase to form hypotaurine.

It is unclear whether hypotaurine is then spontaneously or enzymatically oxidized to yield taurine.

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Taurine in the pharmaceutical and lab setting is synthesized through a combination of cysteine, methionine, and vitamin E.

It is naturally produced in the testicles of many mammals.

Urban legends surrounding the source of taurine have included bull urine extract and bull semen.

While it's true that taurine is found in both sources, it is not the source of taurine in the pharmaceutical or food industry.

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Physiological roles

Taurine is conjugated via its amino terminal group with chenodeoxycholic acid and cholic acid to form the bile salts sodium taurochenodeoxycholate and sodium taurocholate.

The low pKa (1.5) of taurine's sulfonic acid group ensures that this moiety is negatively charged in the pH ranges normally found in the intestinal tract and thus improves the surfactant properties of the cholic acid conjugate, which can be found in many energy drinks today.

Taurine crosses the blood-brain barrier and has been implicated in a wide array of physiological phenomena including inhibitory neurotransmission, long-term potentiation in the striatum/hippocampus, membrane stabilization, feedback inhibition of neutrophil/macrophage respiratory burst, adipose tissue regulation and possible prevention of obesity, calcium homeostasis, recovery from osmotic shock, protection against glutamate excitotoxicity and prevention of epileptic seizures.

It also acts as an antioxidant and protects against toxicity of various substances (such as lead and cadmium).

Additionally, supplementation with taurine has been shown to prevent oxidative stress induced by exercise.

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It is believed that prematurely born infants lack the enzymes needed to convert cystathionine to cysteine and may therefore become deficient in taurine.

Thus, taurine is thought to be a dietary essential nutrient in these individuals and has been added to many infant formulas as a measure of prudence, since the early 1980s.

However, this practice has never been rigorously studied, and as such it has yet to be proven to be beneficial, or even necessary.

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There is also evidence that taurine is beneficial for adult human blood pressure and possibly, the alleviation of other cardiovascular ailments (in humans suffering essential hypertension, taurine supplementation resulted in measurable decreases in blood pressure).

In a recent 2008 study, taurine has been shown to reduce the secretion of apolipoprotein B100 and lipids in HepG2 cells.

High concentrations of serum lipids and apolipoprotein B100 (essential structural component of VLDL and LDL) are major risk factors of atherosclerosis and coronary heart disease. Hence, it is possible that taurine supplementation is beneficial for the prevention of these diseases.

In a 2003 study, Zhang et al. have demonstrated the hypocholesterolemic (blood cholesterol-lowering) effect of dietary taurine in young overweight adults.

Furthermore, they reported that body weight also reduced significantly in the taurine supplemented group.

These findings are consistent with animal studies.

Taurine has also been shown to help people with congestive heart failure by increasing the force and effectiveness of heart-muscle contractions.

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Taurine levels were found to be significantly lower in vegans than in a control group on a standard American diet.

Plasma taurine was 78% of control values, and urinary taurine 29%.

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In the cell, taurine keeps potassium and magnesium inside the cell while keeping excessive sodium out.

In this sense it works like a diuretic.

But unlike prescription diuretics, it is not a cellular poison.

Because it aids the movement of potassium, sodium, and calcium in and out of the cell, taurine has been used as a supplementation for epileptics as well as for people who have uncontrollable facial twitches.

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According to animal studies, taurine produces anxiolytic effect and may act as a modulator or anti-anxiety agent in the central nervous system.

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Taurine is necessary for normal skeletal muscle functioning.

This was shown by a 2004 study, using mice with a genetic taurine deficiency.

They had a nearly complete depletion of skeletal and cardiac muscle taurine levels.

These mice had a reduction of more than 80% of exercise capacity compared to control mice.

The authors expressed themselves as "surprised" that cardiac function showed as largely normal (given various other studies about effects of taurine on the heart).

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Studies have shown that taurine can influence (and possibly reverse) defects in nerve blood flow, motor nerve conduction velocity, and nerve sensory thresholds in experimental diabetic neuropathic rats.

In another study on diabetic rats, taurine significantly decreased weight and decreased blood sugar in these animal models.

Likewise, a 2008 study demonstrated that taurine administration to diabetic rabbits resulted in 30% decrease in serum glucose levels.

According to the single study on human subjects, daily administration of 1.5g taurine had no significant effect on insulin secretion or insulin sensitivity.

However it is possible that an effect may occur at higher dosages.

There is evidence that taurine may exert a beneficial effect in preventing diabetes-associated microangiopathy and tubulointerstitial injury in diabetic nephropathy.

Taurine acts as a glycation inhibitor.

Studies have shown that taurine treated diabetic rats had a decrease in the formation of advanced glycation end products (AGEs) and AGEs content.

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Lately, cosmetic compositions containing taurine have been introduced, possibly due to its antifibrotic properties.

It has been shown that taurine acts as a TGFB1 inhibitor.

It also helps to maintain skin hydration.

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Taurine is also used in some contact lens solutions.

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Taurine and cats

Taurine is essential for feline health, as cats cannot synthesize the compound.

The absence of taurine causes a cat's retina to slowly degenerate, causing eye problems and (eventually) irreversible blindness — a condition known as central retinal degeneration (CRD),as well as hair loss and tooth decay.

It was discovered in 1987 that taurine deficiency can also cause feline dilated cardiomyopathy.

Unlike CRD, the condition is reversible with supplementation.

Taurine is now a requirement of the Association of American Feed Control Officials (AAFCO) and any dry or wet food product labeled approved by the AAFCO should have a minimum of 0.1% taurine in dry food and 0.2% in wet food.

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Taurine and bird development

Recent research has provided evidence that taurine is essential in early bird development of passerines.

Many passerines, regardless of spider availability, seek out many taurine-rich spiders to feed their young particularly in their youngest stages of life.

Researchers later compared the behaviors and development of birds fed a taurine-supplemented diet to a control diet and found that juveniles that were fed taurine-rich diets as neonates were much larger risk takers and more adept at spatial learning tasks.

Synthesis and production

In 1993, approximately 5,000–6,000 t. of taurine was produced; 50% for pet food manufacture, 50% in pharmaceutical applications.

Synthetic taurine is obtained from isethionic acid (2-hydroxyethanesulfonic acid), which in turn is obtained from the reaction of ethylene oxide with aqueous sodium bisulfite.

Another approach is the reaction of aziridine with sulfurous acid. This leads directly to taurine.

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As a functional food

Taurine is used as a functional food in many energy drinks and energy products.

Despite being present in many energy foods, it has not been proven to be energy-giving.

A study of mice hereditarily unable to transport taurine suggests that it is needed for proper maintenance and functioning of skeletal muscles.

Additionally, it has been proven effective in removing fatty liver deposits in humans, preventing liver disease, and reducing cirrhosis in rats.

Taurine
IUPAC name	Taurine
Molecular formula	C2H7NO3S
Identifiers
CAS number	107-35-7
PubChem	1123
SMILES	NCCS(=O)(O)=O
ChemSpider ID	1091
Properties
Molar mass	125.14 g/mol
Density	1.734 g/cm³ (at -173.15 °C)
Melting point	305.11 °C
Acidity (pKa)	1.5, 9.06
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references

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Read The complete Article in Wikipedia, Mar 8, 2009

* Taurine. (2009, March 7). In Wikipedia, The Free Encyclopedia.

Retrieved 06:21, March 8, 2009, from

http://en.wikipedia.org/w/index.php?title=

Taurine&oldid=275679563

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Read The complete Article in Wikipedia June 19 2011

** Taurine. (2011, June 2). In Wikipedia, The Free Encyclopedia.

Retrieved 22:12, June 19, 2011, from

http://en.wikipedia.org/w/index.php?title=

Taurine&oldid=432138462

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